von Spreckelsen, Niklas ORCID: 0000-0002-9873-1711, Fadzen, Colin M., Hartrampf, Nina, Ghotmi, Yarah, Wolfe, Justin M., Dubey, Shipra, Yang, Bo Yeun, Kijewski, Marie F., Wang, Shuyan, Farquhar, Charlotte, Bergmann, Sonja, Zdioruk, Mykola, Wasserburg, J. Roscoe, Scott, Benjamin, Murrell, Emily, Bononi, Fernanda C., Luyt, Leonard G., DiCarli, Marcelo, Lamfers, Martine L. M., Ligon, Keith L., Chiocca, E. Antonio, Viapiano, Mariano S., Pentelute, Bradley L., Lawler, Sean E. and Cho, Choi-Fong (2021). Targeting Glioblastoma Using a Novel Peptide Specific to a Deglycosylated Isoform of Brevican. Adv. Therap., 4 (4). HOBOKEN: WILEY. ISSN 2366-3987

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Abstract

Glioblastoma (GBM) is the most common and deadliest form of brain tumor and remains amongst the most difficult cancers to treat. Brevican (Bcan), a central nervous system (CNS)-specific extracellular matrix protein, is upregulated in high-grade glioma cells, including GBM. A Bcan isoform lacking most glycosylation, dg-Bcan, is found only in GBM tissues. Here, dg-Bcan is explored as a molecular target for GBM. In this study, a d-peptide library is screened to identify a small 8-amino acid dg-Bcan-Targeting Peptide (BTP) candidate, called BTP-7 that binds dg-Bcan with high affinity and specificity. BTP-7 is preferentially internalized by dg-Bcan-expressing patient-derived GBM cells. To demonstrate GBM targeting, BTP-7 is radiolabeled with F-18, a radioisotope of fluorine, and increased radiotracer accumulation is found in intracranial GBM established in mice using positron emission tomography (PET) imaging. dg-Bcan is an attractive molecular target for GBM, and BTP-7 represents a promising lead candidate for further development into novel imaging agents and targeted therapeutics.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
von Spreckelsen, NiklasUNSPECIFIEDorcid.org/0000-0002-9873-1711UNSPECIFIED
Fadzen, Colin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartrampf, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghotmi, YarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfe, Justin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubey, ShipraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, Bo YeunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kijewski, Marie F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, ShuyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farquhar, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zdioruk, MykolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasserburg, J. RoscoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murrell, EmilyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bononi, Fernanda C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luyt, Leonard G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
DiCarli, MarceloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamfers, Martine L. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ligon, Keith L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chiocca, E. AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viapiano, Mariano S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pentelute, Bradley L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lawler, Sean E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cho, Choi-FongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-598978
DOI: 10.1002/adtp.202000244
Journal or Publication Title: Adv. Therap.
Volume: 4
Number: 4
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2366-3987
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59897

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