Universität zu Köln

Wijburg, Martijn T., Warnke, Clemens ORCID: 0000-0002-3510-9255, McGuigan, Christopher, Koralnik, Igor J., Barkhof, Frederik ORCID: 0000-0003-3543-3706, Killestein, Joep and Wattjes, Mike P. (2021). Pharmacovigilance during treatment of multiple sclerosis: early recognition of CNS complications. J. Neurol. Neurosurg. Psychiatry, 92 (2). S. 177 - 189. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-330X

Full text not available from this repository.

Abstract

An increasing number of highly effective disease-modifying therapies for people with multiple sclerosis (MS) have recently gained marketing approval. While the beneficial effects of these drugs in terms of clinical and imaging outcome measures is welcomed, these therapeutics are associated with substance-specific or group-specific adverse events that include severe and fatal complications. These adverse events comprise both infectious and non-infectious complications that can occur within, or outside of the central nervous system (CNS). Awareness and risk assessment strategies thus require interdisciplinary management, and robust clinical and paraclinical surveillance strategies. In this review, we discuss the current role of MRI in safety monitoring during pharmacovigilance of patients treated with (selective) immune suppressive therapies for MS. MRI, particularly brain MRI, has a pivotal role in the early diagnosis of CNS complications that potentially are severely debilitating and may even be lethal. Early recognition of such CNS complications may improve functional outcome and survival, and thus knowledge on MRI features of treatment-associated complications is of paramount importance to MS clinicians, but also of relevance to general neurologists and radiologists.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wijburg, Martijn T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED orcid.org/0000-0002-3510-9255 UNSPECIFIED McGuigan, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Koralnik, Igor J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barkhof, Frederik UNSPECIFIED orcid.org/0000-0003-3543-3706 UNSPECIFIED Killestein, Joep UNSPECIFIED UNSPECIFIED UNSPECIFIED Wattjes, Mike P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-599321
DOI:	10.1136/jnnp-2020-324534
Journal or Publication Title:	J. Neurol. Neurosurg. Psychiatry
Volume:	92
Number:	2
Page Range:	S. 177 - 189
Date:	2021
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-330X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; MAGNIMS CONSENSUS GUIDELINES; HERPES-SIMPLEX ENCEPHALITIS; GRANULE CELL NEURONOPATHY; NERVOUS-SYSTEM LYMPHOMAS; ZOSTER-VIRUS INFECTIONS; FUMARIC-ACID ESTERS; JC VIRUS; CRYPTOCOCCAL MENINGITIS; LISTERIA-MONOCYTOGENES Multiple languages Clinical Neurology; Psychiatry; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59932