Universität zu Köln

van Zanten, Henriette A., Kuypers, Kristel L. A. M., van Zwet, Erik W., van Vonderen, Jeroen J., Kamlin, C. Omar F., Springer, Laila, Lista, Gianluca, Cavigioli, Francesco, Vento, Maximo, Nunez-Ramiro, Antonio, Oberthuer, Andre, Kribs, Angela, Kuester, Helmut, Horn, Sebastian ORCID: 0000-0003-2501-1948, Weinberg, Danielle D., Foglia, Elizabeth E., Morley, Colin J., Davis, Peter G. and te Pas, Arjan B. (2021). A multi-centre randomised controlled trial of respiratory function monitoring during stabilisation of very preterm infants at birth. Resuscitation, 167. S. 317 - 326. CLARE: ELSEVIER IRELAND LTD. ISSN 1873-1570

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Abstract

Aim: To determine whether the use of a respiratory function monitor (RFM) during PPV of extremely preterm infants at birth, compared with no RFM, leads to an increase in percentage of inflations with an expiratory tidal volume (Vte) within a predefined target range. Methods: Unmasked, randomised clinical trial conducted October 2013 - May 2019 in 7 neonatal intensive care units in 6 countries. Very preterm infants (24-27 weeks of gestation) receiving PPV at birth were randomised to have a RFM screen visible or not. The primary outcome was the median proportion of inflations during manual PPV (face mask or intubated) within the target range (Vte 4-8 mL/kg). There were 42 other prespecified monitor measurements and clinical outcomes. Results: Among 288 infants randomised (median (IQR) gestational age 26(+2) (25(+3)-27(+1)) weeks), a total number of 51,352 inflations were analysed. The median (IQR) percentage of inflations within the target range in the RFM visible group was 30.0 (18.0-42.2)% vs 30.2 (14.8-43.1)% in the RFM non-visible group (p = 0.721). There were no dierences in other respiratory function measurements, oxygen saturation, heart rate or FiO(2). There were no dierences in clinical outcomes, except for the incidence of intraventricular haemorrhage (all grades) and/or cystic periventricular leukomalacia (visible RFM: 26.7% vs non-visible RFM: 39.0%; RR 0.71 (0.68-0.97); p = 0.028). Conclusion: In very preterm infants receiving PPV at birth, the use of a RFM, compared to no RFM as guidance for tidal volume delivery, did not increase the percentage of inflations in a predefined target range.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Zanten, Henriette A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuypers, Kristel L. A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Zwet, Erik W. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Vonderen, Jeroen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamlin, C. Omar F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Springer, Laila UNSPECIFIED UNSPECIFIED UNSPECIFIED Lista, Gianluca UNSPECIFIED UNSPECIFIED UNSPECIFIED Cavigioli, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Vento, Maximo UNSPECIFIED UNSPECIFIED UNSPECIFIED Nunez-Ramiro, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberthuer, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuester, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Sebastian UNSPECIFIED orcid.org/0000-0003-2501-1948 UNSPECIFIED Weinberg, Danielle D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foglia, Elizabeth E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morley, Colin J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Davis, Peter G. UNSPECIFIED UNSPECIFIED UNSPECIFIED te Pas, Arjan B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-599452
DOI:	10.1016/j.resuscitation.2021.07.012
Journal or Publication Title:	Resuscitation
Volume:	167
Page Range:	S. 317 - 326
Date:	2021
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1873-1570
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MASK VENTILATION; DELIVERY ROOM; NEONATAL RESUSCITATION; VOLUME; TUBE Multiple languages Critical Care Medicine; Emergency Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59945