Universität zu Köln

Jost, Stefanie T., Chaudhuri, K. Ray, Ashkan, Keyoumars, Loehrer, Philipp A., Silverdale, Monty, Rizos, Alexandra, Evans, Julian, Petry-Schmelzer, Jan Niklas, Barbe, Michael T. ORCID: 0000-0003-1149-8054, Sauerbier, Anna ORCID: 0000-0003-0966-5933, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Visser-Vandewalle, Veerle, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo, Timmermann, Lars and Dafsari, Haidar S. (2021). Subthalamic Stimulation Improves Quality of Sleep in Parkinson Disease: A 36-Month Controlled Study. J. Parkinsons Dis., 11 (1). S. 323 - 336. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Sleep disturbances and neuropsychiatric symptoms are some of the most common nonmotor symptoms in Parkinson's disease (PD). The effect of subthalamic stimulation (STN-DBS) on these symptoms beyond a short-term follow-up is unclear. Objective: To examine 36-month effects of bilateral STN-DBS on quality of sleep, depression, anxiety, and quality of life (QoL) compared to standard-of-care medical therapy (MED) in PD. Methods: In this prospective, controlled, observational, propensity score matched, international multicenter study, we assessed sleep disturbances using the PDSleep Scale-1 (PDSS), QoL employing the PDQuestionnaire-8 (PDQ-8), motor disorder with the Scales for Outcomes in PD (SCOPA), anxiety and depression with the Hospital Anxiety and Depression Scale (HADS), and dopaminergic medication requirements (LEDD). Within-group longitudinal outcome changes were tested using Wilcoxon signed-rank and between-group longitudinal differences of change scores with Mann-Whitney U tests. Spearman correlations analyzed the relationships of outcome parameter changes at follow-up. Results: Propensity score matching applied on 159 patients (STN-DBS n = 75, MED n= 84) resulted in 40 patients in each treatment group. At 36-month follow-up, STN-DBS led to significantly better PDSS and PDQ-8 change scores, which were significantly correlated. We observed no significant effects for HADS and no significant correlations between change scores in PDSS, HADS, and LEDD. Conclusions: We report Class IIb evidence of beneficial effects of STN-DBS on quality of sleep at 36-month follow-up, which were associated with QoL improvement independent of depression and dopaminergic medication. Our study highlights the importance of sleep for assessments of DBS outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jost, Stefanie T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED Ashkan, Keyoumars UNSPECIFIED UNSPECIFIED UNSPECIFIED Loehrer, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Silverdale, Monty UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Evans, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, Jan Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED orcid.org/0000-0003-1149-8054 UNSPECIFIED Sauerbier, Anna UNSPECIFIED orcid.org/0000-0003-0966-5933 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonini, Angelo UNSPECIFIED orcid.org/0000-0003-1040-2807 UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-599968
DOI:	10.3233/JPD-202278
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	11
Number:	1
Page Range:	S. 323 - 336
Date:	2021
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; NUCLEUS STIMULATION; NEUROSTIMULATION; FORCE; SCALE; MOOD; DISTURBANCES; PRAMIPEXOLE; SYMPTOMS; DISORDER Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59996