Schedlich-Teufer, Charlotte, Jost, Stefanie Theresa, Krack, Paul, Witt, Karsten, Weintraub, Daniel, Baldermann, Juan Carlos, Sommerauer, Michael, Amstutz, Deborah, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Dafsari, Haidar Salimi, Kalbe, Elke, Visser-Vandewalle, Veerle, Fink, Gereon Rudolf, Kessler, Josef and Barbe, Michael Thomas (2021). Assessment of Affective-Behavioral States in Parkinson's Disease Patients: Towards a New Screening Tool. J. Parkinsons Dis., 11 (3). S. 1417 - 1431. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Assessment of affective-behavioral states in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS) is essential. Objective: To analyze well-established questionnaires as a pilot-study with the long term aim to develop a screening tool evaluating affective-behavioral dysfunction, including depression, anxiety, apathy, mania, and impulse control disorders, in PD patients screened for DBS. Methods: Two hundred ninety-seven inpatients with PD underwent standardized neuropsychiatric testing including German versions of Beck Depression Inventory-II, Hospital Anxiety and Depression Scale, Apathy Evaluation Scale, Self-Report Manic Inventory, and Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale, to assess appropriateness for DBS. Statistical item reduction was based on exploratory factor analysis, Cronbach's alpha, item-total correlations, item difficulty, and inter-item correlations. Confirmatory factor analysis was conducted to assess factorial validity. An expert rating was performed to identify clinically relevant items in the context of PD and DBS, to maintain content validity. We compared the shortened subscales with the original questionnaires using correlations. To determine cutoff points, receiver operating characteristics analysis was performed. Results: The items of the initial questionnaires were reduced from 129 to 38 items. Results of confirmatory factor analyses supported the validity of the shortened pool. It demonstrated high internal consistency (Cronbach's alpha = 0.72-0.83 across subscales), and the individual subscales were correlated with the corresponding original scales (r(s) = 0.84-0.95). Sensitivities and specificities exceeded 0.7. Conclusion: The shortened item pool, including 38 items, provides a good basis for the development of a screening tool, capturing affective-behavioral symptoms in PD patients before DBS implantation. Confirmation of the validity of such a screening tool in an independent sample of PD patients is warranted.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schedlich-Teufer, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jost, Stefanie TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krack, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weintraub, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldermann, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sommerauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amstutz, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDorcid.org/0000-0002-6951-2325UNSPECIFIED
Dafsari, Haidar SalimiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-600226
DOI: 10.3233/JPD-202375
Journal or Publication Title: J. Parkinsons Dis.
Volume: 11
Number: 3
Page Range: S. 1417 - 1431
Date: 2021
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1877-718X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; IMPULSIVE-COMPULSIVE DISORDERS; RATING-SCALE; SUBTHALAMIC STIMULATION; HOSPITAL ANXIETY; FIT INDEXES; APATHY; QUESTIONNAIRE; MULTICENTER; VALIDATIONMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60022

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