Universität zu Köln

Neofytos, Dionysios ORCID: 0000-0001-6970-2869, Garcia-Vidal, Carolina, Lamoth, Frederic ORCID: 0000-0002-1023-5597, Lichtenstern, Christoph, Perrella, Alessandro and Vehreschild, Joerg Janne (2021). Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response. BMC Infect. Dis., 21 (1). LONDON: BMC. ISSN 1471-2334

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Abstract

BackgroundInvasive aspergillosis (IA) is a rare complication in solid organ transplant (SOT) recipients. Although IA has significant implications on graft and patient survival, data on diagnosis and management of this infection in SOT recipients are still limited.MethodsDiscussion of current practices and limitations in the diagnosis, prophylaxis, and treatment of IA and proposal of means of assessing treatment response in SOT recipients.ResultsLiver, lung, heart or kidney transplant recipients have common as well as different risk factors to the development of IA, thus each category needs a separate evaluation. Diagnosis of IA in SOT recipients requires a high degree of awareness, because established diagnostic tools may not provide the same sensitivity and specificity observed in the neutropenic population. IA treatment relies primarily on mold-active triazoles, but potential interactions with immunosuppressants and other concomitant therapies need special attention.ConclusionsCriteria to assess response have not been sufficiently evaluated in the SOT population and CT lesion dynamics, and serologic markers may be influenced by the underlying disease and type and severity of immunosuppression. There is a need for well-orchestrated efforts to study IA diagnosis and management in SOT recipients and to develop comprehensive guidelines for this population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neofytos, Dionysios UNSPECIFIED orcid.org/0000-0001-6970-2869 UNSPECIFIED Garcia-Vidal, Carolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lamoth, Frederic UNSPECIFIED orcid.org/0000-0002-1023-5597 UNSPECIFIED Lichtenstern, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Perrella, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Joerg Janne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600455
DOI:	10.1186/s12879-021-05958-3
Journal or Publication Title:	BMC Infect. Dis.
Volume:	21
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2334
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPOSOMAL AMPHOTERICIN-B; LATERAL-FLOW DEVICE; BRONCHOALVEOLAR LAVAGE FLUID; HIGH-RISK PATIENTS; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; MYCOSES STUDY-GROUP; FUNGAL-INFECTIONS; PULMONARY ASPERGILLOSIS; ANTIFUNGAL PROPHYLAXIS; MOLD DISEASE Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60045