Universität zu Köln

Kamrath, Clemens, Rosenbauer, Joachim, Eckert, Alexander J., Pappa, Angeliki, Reschke, Felix, Rohrer, Tilman R. ORCID: 0000-0001-9516-7863, Moenkemoeller, Kirsten, Wurm, Michael, Hake, Kathrin, Raile, Klemens and Holl, Reinhard W. (2021). Incidence of COVID-19 and Risk of Diabetic Ketoacidosis in New-Onset Type 1 Diabetes. Pediatrics, 148 (3). ELK GROVE VILLAGE: AMER ACAD PEDIATRICS. ISSN 1098-4275

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Abstract

OBJECTIVES: With this study, our aim was to quantify the relative risk (RR) of diabetic ketoacidosis at diagnosis of type 1 diabetes during the year 2020 and to assess whether it was associated with the regional incidence of coronavirus disease 2019 (COVID-19) cases and deaths. METHODS: Multicenter cohort study based on data from the German Diabetes Prospective Follow-up Registry. The monthly RR for ketoacidosis in 2020 was estimated from observed and expected rates in 3238 children with new-onset type 1 diabetes. Expected rates were derived from data from 2000 to 2019 by using a multivariable logistic trend regression model. The association between the regional incidence of COVID-19 and the rate of ketoacidosis was investigated by applying a log-binomial mixed-effects model to weekly data with Germany divided into 5 regions. RESULTS: The observed versus expected frequency of diabetic ketoacidosis was significantly higher from April to September and in December (mean adjusted RRs, 1.48-1.96). During the first half of 2020, each increase in the regional weekly incidence of COVID-19 by 50 cases or 1 death per 100 000 population was associated with an increase in the RR of diabetic ketoacidosis of 1.40 (95% confidence interval, 1.10-1.77; P 5.006) and 1.23 (1.14-1.32; P <.001), respectively. This association was no longer evident during the second half of 2020. CONCLUSIONS: These findings suggest that the local severity of the pandemic rather than health policy measures appear to be the main reason for the increase in diabetic ketoacidosis and thus the delayed use of health care during the pandemic.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kamrath, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenbauer, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckert, Alexander J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pappa, Angeliki UNSPECIFIED UNSPECIFIED UNSPECIFIED Reschke, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohrer, Tilman R. UNSPECIFIED orcid.org/0000-0001-9516-7863 UNSPECIFIED Moenkemoeller, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Wurm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Hake, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Raile, Klemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600777
DOI:	10.1542/peds.2021-050856
Journal or Publication Title:	Pediatrics
Volume:	148
Number:	3
Date:	2021
Publisher:	AMER ACAD PEDIATRICS
Place of Publication:	ELK GROVE VILLAGE
ISSN:	1098-4275
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MYOCARDIAL-INFARCTION; LOCKDOWN Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60077