Universität zu Köln

Palleis, Carla, Brendel, Matthias, Finze, Anika, Weidinger, Endy, Boetzel, Kai, Danek, Adrian ORCID: 0000-0001-8857-5383, Beyer, Leonie, Nitschmann, Alexander, Kern, Maike, Biechele, Gloria, Rauchmann, Boris-Stephan, Haeckert, Jan ORCID: 0000-0002-4319-5034, Hoellerhage, Matthias, Stephens, Andrew W., Drzezga, Alexander ORCID: 0000-0001-6018-716X, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Villemagne, Victor L., Schildan, Andreas, Barthel, Henryk, Patt, Marianne, Sabri, Osama, Bartenstein, Peter, Perneczky, Robert, Haass, Christian, Levin, Johannes ORCID: 0000-0001-5092-4306 and Hoeglinger, Guenter U. (2021). Cortical [F-18]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes. Mov. Disord., 36 (9). S. 2104 - 2116. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background Corticobasal syndrome is associated with cerebral protein aggregates composed of 4-repeat (similar to 50% of cases) or mixed 3-repeat/4-repeat tau isoforms (similar to 25% of cases) or nontauopathies (similar to 25% of cases). Objectives The aim of this single-center study was to investigate the diagnostic value of the tau PET-ligand [F-18]PI-2620 in patients with corticobasal syndrome. Methods Forty-five patients (71.5 +/- 7.6 years) with corticobasal syndrome and 14 age-matched healthy controls underwent [F-18]PI-2620-PET. Beta-amyloid status was determined by cerebral beta-amyloid PET and/or CSF analysis. Subcortical and cortical [F-18]PI-2620 binding was quantitatively and visually compared between beta-amyloid-positive and -negative patients and controls. Regional [F-18]PI-2620 binding was correlated with clinical and demographic data. Results Twenty-four percent (11 of 45) were beta-amyloid-positive. Significantly elevated [F-18]PI-2620 distribution volume ratios were observed in both beta-amyloid-positive and beta-amyloid-negative patients versus controls in the dorsolateral prefrontal cortex and basal ganglia. Cortical [F-18]PI-2620 PET positivity was distinctly higher in beta-amyloid-positive compared with beta-amyloid-negative patients with pronounced involvement of the dorsolateral prefrontal cortex. Semiquantitative analysis of [F-18]PI-2620 PET revealed a sensitivity of 91% for beta-amyloid-positive and of 65% for beta-amyloid-negative cases, which is in excellent agreement with prior clinicopathological data. Regardless of beta-amyloid status, hemispheric lateralization of [F-18]PI-2620 signal reflected contralateral predominance of clinical disease severity. Conclusions Our data indicate a value of [F-18]PI-2620 for evaluating corticobasal syndrome, providing quantitatively and regionally distinct signals in beta-amyloid-positive as well as beta-amyloid-negative corticobasal syndrome. In corticobasal syndrome, [F-18]PI-2620 may potentially serve for a differential diagnosis and for monitoring disease progression. (c) 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Palleis, Carla UNSPECIFIED UNSPECIFIED UNSPECIFIED Brendel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Finze, Anika UNSPECIFIED UNSPECIFIED UNSPECIFIED Weidinger, Endy UNSPECIFIED UNSPECIFIED UNSPECIFIED Boetzel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Danek, Adrian UNSPECIFIED orcid.org/0000-0001-8857-5383 UNSPECIFIED Beyer, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Nitschmann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kern, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Biechele, Gloria UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauchmann, Boris-Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeckert, Jan UNSPECIFIED orcid.org/0000-0002-4319-5034 UNSPECIFIED Hoellerhage, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Stephens, Andrew W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Villemagne, Victor L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildan, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Barthel, Henryk UNSPECIFIED UNSPECIFIED UNSPECIFIED Patt, Marianne UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabri, Osama UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartenstein, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Perneczky, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Haass, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Levin, Johannes UNSPECIFIED orcid.org/0000-0001-5092-4306 UNSPECIFIED Hoeglinger, Guenter U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601355
DOI:	10.1002/mds.28624
Journal or Publication Title:	Mov. Disord.
Volume:	36
Number:	9
Page Range:	S. 2104 - 2116
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60135