Universität zu Köln

Samayoa, Luis Fernando ORCID: 0000-0001-9651-9939, Olukolu, Bode A., Yang, Chin Jian, Chen, Qiuyue ORCID: 0000-0002-3304-8321, Stetter, Markus G., York, Alessandra M., Sanchez-Gonzalez, Jose de Jesus, Glaubitz, Jeffrey C., Bradbury, Peter J., Romay, Maria Cinta, Sun, Qi, Yang, Jinliang, Ross-Ibarra, Jeffrey, Buckler, Edward S., Doebley, John F. and Holland, James B. (2021). Domestication reshaped the genetic basis of inbreeding depression in a maize landrace compared to its wild relative, teosinte. PLoS Genet., 17 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7404

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Abstract

Inbreeding depression is the reduction in fitness and vigor resulting from mating of close relatives observed in many plant and animal species. The extent to which the genetic load of mutations contributing to inbreeding depression is due to large-effect mutations versus variants with very small individual effects is unknown and may be affected by population history. We compared the effects of outcrossing and self-fertilization on 18 traits in a landrace population of maize, which underwent a population bottleneck during domestication, and a neighboring population of its wild relative teosinte. Inbreeding depression was greater in maize than teosinte for 15 of 18 traits, congruent with the greater segregating genetic load in the maize population that we predicted from sequence data. Parental breeding values were highly consistent between outcross and selfed offspring, indicating that additive effects determine most of the genetic value even in the presence of strong inbreeding depression. We developed a novel linkage scan to identify quantitative trait loci (QTL) representing large-effect rare variants carried by only a single parent, which were more important in teosinte than maize. Teosinte also carried more putative juvenile-acting lethal variants identified by segregation distortion. These results suggest a mixture of mostly polygenic, small-effect partially recessive effects in linkage disequilibrium underlying inbreeding depression, with an additional contribution from rare larger-effect variants that was more important in teosinte but depleted in maize following the domestication bottleneck. Purging associated with the maize domestication bottleneck may have selected against some large effect variants, but polygenic load is harder to purge and overall segregating mutational burden increased in maize compared to teosinte.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Samayoa, Luis Fernando UNSPECIFIED orcid.org/0000-0001-9651-9939 UNSPECIFIED Olukolu, Bode A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Chin Jian UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Qiuyue UNSPECIFIED orcid.org/0000-0002-3304-8321 UNSPECIFIED Stetter, Markus G. UNSPECIFIED UNSPECIFIED UNSPECIFIED York, Alessandra M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanchez-Gonzalez, Jose de Jesus UNSPECIFIED UNSPECIFIED UNSPECIFIED Glaubitz, Jeffrey C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bradbury, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Romay, Maria Cinta UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Qi UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Jinliang UNSPECIFIED UNSPECIFIED UNSPECIFIED Ross-Ibarra, Jeffrey UNSPECIFIED UNSPECIFIED UNSPECIFIED Buckler, Edward S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doebley, John F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holland, James B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601614
DOI:	10.1371/journal.pgen.1009797
Journal or Publication Title:	PLoS Genet.
Volume:	17
Number:	12
Date:	2021
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7404
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REPRODUCTIVE ISOLATION; POPULATION-STRUCTURE; EVOLUTION; PATTERNS; TRAITS; ASSOCIATION; HETEROSIS; SELECTION; SELF; OVERDOMINANCE Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60161