Universität zu Köln

Meintrup, David, Borgmann, Stefan, Seidl, Karlheinz, Stecher, Melanie, Jakob, Carolin E. M., Pilgram, Lisa, Spinner, Christoph D., Rieg, Siegbert, Isberner, Nora ORCID: 0000-0001-7217-9191, Hower, Martin ORCID: 0000-0001-5967-5238, Vehreschild, Maria, Goepel, Siri ORCID: 0000-0002-7666-4634, Hanses, Frank ORCID: 0000-0002-0007-8014 and Nowak-Machen, Martina (2021). Specific Risk Factors for Fatal Outcome in Critically Ill COVID-19 Patients: Results from a European Multicenter Study. J. Clin. Med., 10 (17). BASEL: MDPI. ISSN 2077-0383

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Abstract

(1) Background: The aim of our study was to identify specific risk factors for fatal outcome in critically ill COVID-19 patients. (2) Methods: Our data set consisted of 840 patients enclosed in the LEOSS registry. Using lasso regression for variable selection, a multifactorial logistic regression model was fitted to the response variable survival. Specific risk factors and their odds ratios were derived. A nomogram was developed as a graphical representation of the model. (3) Results: 14 variables were identified as independent factors contributing to the risk of death for critically ill COVID-19 patients: age (OR 1.08, CI 1.06-1.10), cardiovascular disease (OR 1.64, CI 1.06-2.55), pulmonary disease (OR 1.87, CI 1.16-3.03), baseline Statin treatment (0.54, CI 0.33-0.87), oxygen saturation (unit = 1%, OR 0.94, CI 0.92-0.96), leukocytes (unit 1000/mu L, OR 1.04, CI 1.01-1.07), lymphocytes (unit 100/mu L, OR 0.96, CI 0.94-0.99), platelets (unit 100,000/mu L, OR 0.70, CI 0.62-0.80), procalcitonin (unit ng/mL, OR 1.11, CI 1.05-1.18), kidney failure (OR 1.68, CI 1.05-2.70), congestive heart failure (OR 2.62, CI 1.11-6.21), severe liver failure (OR 4.93, CI 1.94-12.52), and a quick SOFA score of 3 (OR 1.78, CI 1.14-2.78). The nomogram graphically displays the importance of these 14 factors for mortality. (4) Conclusions: There are risk factors that are specific to the subpopulation of critically ill COVID-19 patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meintrup, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgmann, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidl, Karlheinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Stecher, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakob, Carolin E. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilgram, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Spinner, Christoph D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieg, Siegbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Isberner, Nora UNSPECIFIED orcid.org/0000-0001-7217-9191 UNSPECIFIED Hower, Martin UNSPECIFIED orcid.org/0000-0001-5967-5238 UNSPECIFIED Vehreschild, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Goepel, Siri UNSPECIFIED orcid.org/0000-0002-7666-4634 UNSPECIFIED Hanses, Frank UNSPECIFIED orcid.org/0000-0002-0007-8014 UNSPECIFIED Nowak-Machen, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601629
DOI:	10.3390/jcm10173855
Journal or Publication Title:	J. Clin. Med.
Volume:	10
Number:	17
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVASIVE MECHANICAL VENTILATION; CARE-UNIT ADMISSION; HOSPITALIZATION; DEATH Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60162