Universität zu Köln

Schroeter, Michael, Berger, Benjamin, Blaes, Franz, Hagenacker, Tim, Jander, Sebastian, Kaiser, Julia, Kalischewski, Petra, Lee, De-Hyung, Ruck, Tobias ORCID: 0000-0001-6332-8650, Schara, Ulrike, Urban, Peter and Meisel, Andreas ORCID: 0000-0001-7233-5342 (2021). A Sum Score to Define Therapy-Refractory Myasthenia Gravis: A German Consensus. J. Cent. Nerv. Syst. Dis., 13. LONDON: SAGE PUBLICATIONS LTD. ISSN 1179-5735

Full text not available from this repository.

Abstract

Background and purpose: In 2017, eculizumab has been approved for treatment-refractory generalised myasthenia gravis (TRgMG). The German Myasthenia Foundation has published a consensus statement on the use of eculizumab, with a recent update. However, a treatment-refractory state is still ill-defined and the term warrants further clarification. We aimed at developing a sum score to operationalise the definition of a TRgMG status, which is easy- to-handle in clinical decision making. Methods: We established a structured consensus process according to the Delphi consensus methodology, with 12 members of the medical advisory board of the German Myasthenia Foundation. Accordingly, 4 consensus rounds were accomplished. Additionally, a literature survey covering the years 2004-2020 was done and relevant information offered to the consensus group. Consensus criteria were predefined. In the consensus process the relative importance of scoring items were to be consented, with a sum score of 20 and above indicating a TRgMG status. Results: The sum score considers the categories disease severity, inefficiency of antecedent therapies, cessation of therapies due to side effects, and long term stay on the intensive care unit. Categories were specified by a total of 13 scoring items. Eventually, the Delphi process developed an unanimous scoring consensus. Conclusion: We suggest a sum score to define treatment refractory state in generalised myasthenia gravis. Beyond clarifying the indication of eculizumab, this easy-to-handle score facilitates clinical decision making and offers new inclusion criteria for clinical studies that explore new therapeutic perspectives in myasthenia gravis treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaes, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagenacker, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Jander, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalischewski, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, De-Hyung UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruck, Tobias UNSPECIFIED orcid.org/0000-0001-6332-8650 UNSPECIFIED Schara, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Urban, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisel, Andreas UNSPECIFIED orcid.org/0000-0001-7233-5342 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601905
DOI:	10.1177/1179573521989151
Journal or Publication Title:	J. Cent. Nerv. Syst. Dis.
Volume:	13
Date:	2021
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1179-5735
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60190