Leta, Valentina ORCID: 0000-0002-5794-7540, Dafsari, Haidar S., Sauerbier, Anna, Metta, Vinod, Titova, Nataliya, Timmermann, Lars, Ashkan, Keyoumars, Samuel, Michael, Pekkonen, Eero, Odin, Per, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo ORCID: 0000-0003-0837-5280, Parry, Miriam, van Wamelen, Daniel J. and Ray Chaudhuri, K. (2021). Personalised Advanced Therapies in Parkinson's Disease: The Role of Non-Motor Symptoms Profile. J. Pers. Med., 11 (8). BASEL: MDPI. ISSN 2075-4426

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Abstract

Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson's disease (PD). Currently, selection of device-aided therapies is mainly focused on patients' motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that specific non-motor symptoms could be used as an additional anchor to motor symptoms and not merely as exclusion criteria to deliver bespoke and patient-specific personalised therapy for advanced PD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Leta, ValentinaUNSPECIFIEDorcid.org/0000-0002-5794-7540UNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauerbier, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metta, VinodUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Titova, NataliyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ashkan, KeyoumarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samuel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pekkonen, EeroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odin, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Martinez-Martin, PabloUNSPECIFIEDorcid.org/0000-0003-0837-5280UNSPECIFIED
Parry, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Wamelen, Daniel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ray Chaudhuri, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-601917
DOI: 10.3390/jpm11080773
Journal or Publication Title: J. Pers. Med.
Volume: 11
Number: 8
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2075-4426
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; CARBIDOPA INTESTINAL GEL; INTRAJEJUNAL LEVODOPA INFUSION; SUBCUTANEOUS APOMORPHINE; MOTOR; NEUROSTIMULATION; COMPLICATIONS; MULTICENTER; IMPACT; FORCEMultiple languages
Health Care Sciences & Services; Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60191

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