Universität zu Köln

Rieder, Marina, Gauchel, Nadine ORCID: 0000-0002-1276-9920, Kaier, Klaus ORCID: 0000-0003-0837-6945, Jakob, Carolin, Borgmann, Stefan, Classen, Annika Y., Schneider, Jochen, Eberwein, Lukas, Lablans, Martin, Ruethrich, Maria, Dolff, Sebastian, Wille, Kai ORCID: 0000-0002-7682-8563, Haselberger, Martina, Heuzeroth, Hanno, Bode, Christoph, Muehlen, Constantin von Zur, Rieg, Siegbert and Duerschmied, Daniel (2022). Pre-medication with oral anticoagulants is associated with better outcomes in a large multinational COVID-19 cohort with cardiovascular comorbidities. Clin. Res. Cardiol., 111 (3). S. 322 - 333. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Aims: Coagulopathy and venous thromboembolism are common findings in coronavirus disease 2019 (COVID-19) and are associated with poor outcome. Timely initiation of anticoagulation after hospital admission was shown to be beneficial. In this study we aim to examine the association of pre-existing oral anticoagulation (OAC) with outcome among a cohort of SARS-CoV-2 infected patients. Methods and results: We analysed the data from the large multi-national Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS) from March to August 2020. Patients with SARS-CoV-2 infection were eligible for inclusion. We retrospectively analysed the association of pre-existing OAC with all-cause mortality. Secondary outcome measures included COVID-19-related mortality, recovery and composite endpoints combining death and/or thrombotic event and death and/or bleeding event. We restricted bleeding events to intracerebral bleeding in this analysis to ensure clinical relevance and to limit reporting errors. A total of 1 433 SARS-CoV-2 infected patients were analysed, while 334 patients (23.3%) had an existing premedication with OAC and 1 099 patients (79.7%) had no OAC. After risk adjustment for comorbidities, pre-existing OAC showed a protective influence on the endpoint death (OR 0.62, P = 0.013) as well as the secondary endpoints COVID-19-related death (OR 0.64, P = 0.023) and non-recovery (OR 0.66, P = 0.014). The combined endpoint death or thrombotic event tended to be less frequent in patients on OAC (OR 0.71, P = 0.056). Conclusions: Pre-existing OAC is protective in COVID-19, irrespective of anticoagulation regime during hospital stay and independent of the stage and course of disease. Graphic abstract

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rieder, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Gauchel, Nadine UNSPECIFIED orcid.org/0000-0002-1276-9920 UNSPECIFIED Kaier, Klaus UNSPECIFIED orcid.org/0000-0003-0837-6945 UNSPECIFIED Jakob, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgmann, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Classen, Annika Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberwein, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lablans, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruethrich, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolff, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wille, Kai UNSPECIFIED orcid.org/0000-0002-7682-8563 UNSPECIFIED Haselberger, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuzeroth, Hanno UNSPECIFIED UNSPECIFIED UNSPECIFIED Bode, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Muehlen, Constantin von Zur UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieg, Siegbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Duerschmied, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602291
DOI:	10.1007/s00392-021-01939-3
Journal or Publication Title:	Clin. Res. Cardiol.
Volume:	111
Number:	3
Page Range:	S. 322 - 333
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-0692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL CHARACTERISTICS; PNEUMONIA Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60229