Universität zu Köln

Zaragori, Timothee, Castello, Angelo, Guedj, Eric, Girard, Antoine, Galldiks, Norbert, Albert, Nathalie L., Lopci, Egesta ORCID: 0000-0001-9732-1094 and Verger, Antoine (2021). Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value A Multicentric C-11-Methionine and F-18-FDOPA PET Experience. Clin. Nucl. Med., 46 (1). S. e36 - 2. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0229

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Abstract

The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used C-11-MET and F-18-FDOPA PET amino acid tracers. Thirty-two C-11-MET and 26 F-18-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 C-11-MET and 10 F-18-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zaragori, Timothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Castello, Angelo UNSPECIFIED UNSPECIFIED UNSPECIFIED Guedj, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Girard, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Albert, Nathalie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lopci, Egesta UNSPECIFIED orcid.org/0000-0001-9732-1094 UNSPECIFIED Verger, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602349
DOI:	10.1097/RLU.0000000000003240
Journal or Publication Title:	Clin. Nucl. Med.
Volume:	46
Number:	1
Page Range:	S. e36 - 2
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-0229
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60234