Universität zu Köln

Heinrich, Maria, Sieg, Miriam, Kruppa, Jochen, Nurnberg, Peter, Schreier, Peter H., Heilmann-Heimbach, Stefanie, Hoffmann, Per, Nothen, Markus M., Janke, Jurgen, Pischon, Tobias ORCID: 0000-0003-1568-767X, Slooter, Arjen J. C., Winterer, Georg and Spies, Claudia D. (2021). Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients. BMC Med. Genomics, 14 (1). LONDON: BMC. ISSN 1755-8794

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Abstract

Background Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic candidate genes according to the Kyoto encyclopedia of genes and genomes - pathway: cholinergic neurotransmission with the development of POD or POCD in elderly patients. Methods This analysis is part of the European BioCog project (), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental-State-Examination score <= 23 points were excluded. POD was assessed up to seven days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. POCD was assessed three months after surgery with a neuropsychological test battery. Genotyping was performed on the Illumina Infinium Global Screening Array. Associations with POD and POCD were analyzed using logistic regression analysis, adjusted for age, comorbidities and duration of anesthesia (for POCD analysis additionally for education). Odds ratios (OR) refer to minor allele counts (0, 1, 2). Results 745 patients could be included in the POD analysis, and 452 in the POCD analysis. The rate of POD within this group was 20.8% (155 patients), and the rate of POCD was 10.2% (46 patients). In a candidate gene approach three genetic variants of the cholinergic genes CHRM2 and CHRM4 were associated with POD (OR [95% confidence interval], rs8191992: 0.61[0.46; 0.80]; rs8191992: 1.60[1.22; 2.09]; rs2067482: 1.64[1.10; 2.44]). No associations were found for POCD. Conclusions We found an association between genetic variants of CHRM2 and CHRM4 and POD. Further studies are needed to investigate whether disturbances in acetylcholine release and synaptic plasticity are involved in the development of POD. Trial registration: ClinicalTrials.gov: NCT02265263.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heinrich, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Sieg, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruppa, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Nurnberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreier, Peter H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heilmann-Heimbach, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Nothen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Janke, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Pischon, Tobias UNSPECIFIED orcid.org/0000-0003-1568-767X UNSPECIFIED Slooter, Arjen J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Winterer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Spies, Claudia D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602847
DOI:	10.1186/s12920-021-01071-1
Journal or Publication Title:	BMC Med. Genomics
Volume:	14
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1755-8794
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK-FACTOR; RECEPTOR; ACETYLCHOLINE; CHRM2; POLYMORPHISMS; BIOMARKERS Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60284