Universität zu Köln

Seidel, Danila, Simon, Michaela, Sprute, Rosanne ORCID: 0000-0003-2457-6437, Lubnow, Matthias ORCID: 0000-0002-4402-1810, Evert, Katja, Speer, Claudius, Seessle, Jessica, Khatamzas, Elham, Merle, Uta, Behrens, Christopher, Blau, Igor Wolfgang, Enghard, Philipp, Haas, Christian S., Steinmann, Joerg, Kurzai, Oliver and Cornely, Oliver A. (2022). Results from a national survey on COVID-19-associated mucormycosis in Germany: 13 patients from six tertiary hospitals. Mycoses, 65 (1). S. 103 - 110. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Background Most COVID-19-associated mucormycosis (CAM) cases are reported from India and neighbouring countries. Anecdotally cases from Europe have been presented. Objective To estimate the disease burden and describe the clinical presentation of CAM in Germany. Methods We identified cases through German mycology networks and scientific societies, and collected anonymised clinical information via FungiScope (R). Results We identified 13 CAM cases from six tertiary referral hospitals diagnosed between March 2020 and June 2021. Twelve patients had severe or critical COVID-19, eleven were mechanically ventilated for a median of 8 days (range 1-27 days) before diagnosis of CAM. Eleven patients received systemic corticosteroids. Additional underlying medical conditions were reported for all but one patient, five were immunocompromised because of malignancy or organ transplantation, three were diabetic. Eleven patients developed pneumonia. Mortality was 53.8% with a median time from diagnosis of mucormycosis to death of 9 days (range 0-214 days) despite treatment with liposomal amphotericin B and/or isavuconazole in 10 of 13 cases. CAM prevalence amongst hospitalised COVID-19 patients overall (0.67% and 0.58% in two centres) and those admitted to the intensive care unit (ICU) (1.47%, 1.78% and 0.15% in three centres) was significantly higher compared to non-COVID-19 patients (P < .001 for respective comparisons). Conclusion COVID-19-associated mucormycosis is rare in Germany, mostly reported in patients with comorbidities and impaired immune system and severe COVID-19 treated in the ICU with high mortality compared to mainly rhino-orbito-cerebral CAM in patients with mild COVID-19 in India. Risk for CAM is higher in hospitalised COVID-19 patients than in other patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seidel, Danila UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Michaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprute, Rosanne UNSPECIFIED orcid.org/0000-0003-2457-6437 UNSPECIFIED Lubnow, Matthias UNSPECIFIED orcid.org/0000-0002-4402-1810 UNSPECIFIED Evert, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Speer, Claudius UNSPECIFIED UNSPECIFIED UNSPECIFIED Seessle, Jessica UNSPECIFIED UNSPECIFIED UNSPECIFIED Khatamzas, Elham UNSPECIFIED UNSPECIFIED UNSPECIFIED Merle, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrens, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Igor Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Enghard, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Christian S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurzai, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603017
DOI:	10.1111/myc.13379
Journal or Publication Title:	Mycoses
Volume:	65
Number:	1
Page Range:	S. 103 - 110
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRITICALLY-ILL PATIENTS; PULMONARY ASPERGILLOSIS; COVID-19; MORTALITY Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60301