Universität zu Köln

Randerath, Winfried J., Herkenrath, Simon, Treml, Marcel, Grote, Ludger, Hedner, Jan, Bonsignore, Maria Rosaria, Pepin, Jean Louis, Ryan, Silke, Schiza, Sophia, Verbraecken, Johan, McNicholas, Walter T., Pataka, Athanasia, Sliwinski, Pawel and Basoglu, Ozen K. (2021). Evaluation of a multicomponent grading system for obstructive sleep apnoea: the Baveno classification. ERJ Open Res., 7 (1). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 2312-0541

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Abstract

New findings on pathophysiology, epidemiology, and outcome have raised concerns on the relevance of the apnoea-hypopnoea index (AHI) in the classification of obstructive sleep apnoea (OSA) severity. Recently, a multicomponent grading system decision integrating symptomatology and comorbidities (Baveno classification), was proposed to characterise OSA and to guide therapeutic decisions. We evaluated whether this system reflects the OSA population, whether it translates into differences in outcomes, and whether the addition of AHI improves the scheme. A total of 14499 OSA patients from the European Sleep Apnoea Database cohort were analysed. The groups were homogeneously distributed and were found to clearly stratify the population with respect to baseline parameters. Differences in sleepiness and blood pressure between the groups were analysed in a subgroup of patients after 24-36 months of treatment. Group A (minor symptoms and comorbidities) did not demonstrate any effect of treatment on outcome. However, groups B (severe symptoms, minor comorbidities), C (minor symptoms, severe comorbidities) and D (severe symptoms and comorbidities) were associated with improvement in either or both parameters with treatment. The AHI is an essential prerequisite of the diagnosis; however, adding the AHI did not improve the classification. Rather, it was inferior with respect to guiding the treatment decision. Thus, the Baveno classification allows a better stratification of the OSA population and may provide a better guidance for therapeutic decisions in OSA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Randerath, Winfried J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herkenrath, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Treml, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Grote, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED Hedner, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonsignore, Maria Rosaria UNSPECIFIED UNSPECIFIED UNSPECIFIED Pepin, Jean Louis UNSPECIFIED UNSPECIFIED UNSPECIFIED Ryan, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiza, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Verbraecken, Johan UNSPECIFIED UNSPECIFIED UNSPECIFIED McNicholas, Walter T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pataka, Athanasia UNSPECIFIED UNSPECIFIED UNSPECIFIED Sliwinski, Pawel UNSPECIFIED UNSPECIFIED UNSPECIFIED Basoglu, Ozen K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603103
DOI:	10.1183/23120541.00928-2020
Journal or Publication Title:	ERJ Open Res.
Volume:	7
Number:	1
Date:	2021
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	2312-0541
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITIVE AIRWAY PRESSURE; RESISTANT HYPERTENSION; PREVALENT; HYPOPNEA; RULES Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60310