Universität zu Köln

Paoletti, Giovanni ORCID: 0000-0003-3953-9225, Di Bona, Danilo, Chu, Derek K., Firinu, Davide ORCID: 0000-0002-5768-391X, Heffler, Enrico ORCID: 0000-0002-0492-5663, Agache, Ioana, Jutel, Marek, Klimek, Ludger, Pfaar, Oliver, Moesges, Ralph, DunnGalvin, Audrey, Genuneit, Jon, Hoffmann, Hans Jurgen and Canonica, Giorgio Walter (2021). Allergen immunotherapy: The growing role of observational and randomized trial Real-World Evidence. Allergy, 76 (9). S. 2663 - 2673. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

Background Although there is a considerable body of knowledge about allergen immunotherapy (AIT), there is a lack of data on the reliability of real-world evidence (RWE) in AIT, and consequently, a lack of information on how AIT effectively works in real life. Methods To address the current unmet need for an appraisal of the quality of RWE in AIT, the European Academy of Allergy and Clinical Immunology Methodology Committee recently initiated a systematic review of observational studies of AIT, which will use the RELEVANT tool and the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE) to rate the quality of the evidence base as a whole. The next step will be to develop a broadly applicable, pragmatic real-world database using systematic data collection. Based on the current RWE base, and perspectives and recommendations of authorities and scientific societies, a hierarchy of RWE in AIT is proposed, which places pragmatic trials and registry data at the positions of highest level of evidence. Key Results There is a need to establish more AIT registries that collect data in a cohesive way, using standardized protocols. Conclusions This will provide an essential source of real-world data that can be easily shared, promoting evidence-based research and quality improvement in study design and clinical decision-making.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Paoletti, Giovanni UNSPECIFIED orcid.org/0000-0003-3953-9225 UNSPECIFIED Di Bona, Danilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Chu, Derek K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Firinu, Davide UNSPECIFIED orcid.org/0000-0002-5768-391X UNSPECIFIED Heffler, Enrico UNSPECIFIED orcid.org/0000-0002-0492-5663 UNSPECIFIED Agache, Ioana UNSPECIFIED UNSPECIFIED UNSPECIFIED Jutel, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimek, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfaar, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED DunnGalvin, Audrey UNSPECIFIED UNSPECIFIED UNSPECIFIED Genuneit, Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Hans Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Canonica, Giorgio Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603603
DOI:	10.1111/all.14773
Journal or Publication Title:	Allergy
Volume:	76
Number:	9
Page Range:	S. 2663 - 2673
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1398-9995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBLINGUAL IMMUNOTHERAPY; RHINITIS; ASTHMA; RHINOCONJUNCTIVITIS; EFFICACY; STANDARDIZATION; GUIDELINES; THERAPY; FORMS; USERS Multiple languages Allergy; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60360