Universität zu Köln

Assa, Amit, Benninga, Marc A., Borrelli, Osvaldo, Broekaert, Ilse, de Carpi, Javier Martin, Saccomani, Marco Deganello, Dolinsek, Jernej, Mas, Emmanuel, Miele, Erasmo, Thomson, Mike and Tzivinikos, Christos (2021). Gastrointestinal Perspective of Coronavirus Disease 2019 in Children-An Updated Review. J. Pediatr. Gastroenterol. Nutr., 73 (3). S. 299 - 306. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4801

Full text not available from this repository.

Abstract

Gastrointestinal symptoms are common findings in children with severe acute respiratory syndrome coronavirus 2 infection, including vomiting, diarrhoea, abdominal pain, and difficulty in feeding, although these symptoms tend to be mild. The hepato-biliary system and the pancreas may also be involved, usually with a mild elevation of transaminases and, rarely, pancreatitis. In contrast, a late hyper-inflammatory phenomenon, termed multisystem inflammatory syndrome (MIS-C), is characterized by more frequent gastrointestinal manifestations with greater severity, sometimes presenting as peritonitis. Gastrointestinal and hepato-biliary manifestations are probably related to a loss in enterocyte absorption capability and microscopic mucosal damage caused by a viral infection of intestinal epithelial cells, hepatocytes and other cells through the angiotensin conversion enzyme 2 receptor resulting in immune cells activation with subsequent release of inflammatory cytokines. Specific conditions such as inflammatory bowel disease (IBD) and liver transplantation may pose a risk for the more severe presentation of coronavirus disease 2019 (COVID-19) but as adult data accumulate, paediatric data is still limited. The aim of this review is to summarize the current evidence about the effect of COVID-19 on the gastrointestinal system in children, with emphasis on the emerging MIS-C and specific considerations such as patients with IBD and liver transplant recipients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Assa, Amit UNSPECIFIED UNSPECIFIED UNSPECIFIED Benninga, Marc A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borrelli, Osvaldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, Ilse UNSPECIFIED UNSPECIFIED UNSPECIFIED de Carpi, Javier Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Saccomani, Marco Deganello UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolinsek, Jernej UNSPECIFIED UNSPECIFIED UNSPECIFIED Mas, Emmanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Miele, Erasmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomson, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzivinikos, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603662
DOI:	10.1097/MPG.0000000000003204
Journal or Publication Title:	J. Pediatr. Gastroenterol. Nutr.
Volume:	73
Number:	3
Page Range:	S. 299 - 306
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4801
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTISYSTEM INFLAMMATORY SYNDROME; LIVER-TRANSPLANT; COVID-19; SARS-COV-2; INFECTION; SYMPTOMS; FEATURES; CHINA Multiple languages Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60366