Universität zu Köln

Wenzel, Julian, Haas, Shalaila S., Dwyer, Dominic B., Ruef, Anne, Oeztuerk, Oemer Faruk, Antonucci, Linda A., von Saldern, Sebastian, Bonivento, Carolina, Garzitto, Marco, Ferro, Adele, Paolini, Marco, Blautzik, Janusch, Borgwardt, Stefan, Brambilla, Paolo, Meisenzahl, Eva, Salokangas, Raimo K. R., Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Wood, Stephen J., Kambeitz, Joseph ORCID: 0000-0002-8988-3959, Koutsouleris, Nikolaos and Kambeitz-Ilankovic, Lana (2021). Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints? Neuropsychopharmacology, 46 (8). S. 1475 - 1484. LONDON: SPRINGERNATURE. ISSN 1740-634X

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Abstract

In schizophrenia, neurocognitive subtypes can be distinguished based on cognitive performance and they are associated with neuroanatomical alterations. We investigated the existence of cognitive subtypes in shortly medicated recent onset psychosis patients, their underlying gray matter volume patterns and clinical characteristics. We used a K-means algorithm to cluster 108 psychosis patients from the multi-site EU PRONIA (Prognostic tools for early psychosis management) study based on cognitive performance and validated the solution independently (N = 53). Cognitive subgroups and healthy controls (HC; n = 195) were classified based on gray matter volume (GMV) using Support Vector Machine classification. A cognitively spared (N = 67) and impaired (N = 41) subgroup were revealed and partially independently validated (N-spared = 40, N-impaired = 13). Impaired patients showed significantly increased negative symptomatology (p(fdr) = 0.003), reduced cognitive performance (p(fdr) < 0.001) and general functioning (p(fdr) < 0.035) in comparison to spared patients. Neurocognitive deficits of the impaired subgroup persist in both discovery and validation sample across several domains, including verbal memory and processing speed. A GMV pattern (balanced accuracy = 60.1%, p = 0.01) separating impaired patients from HC revealed increases and decreases across several fronto-temporal-parietal brain areas, including basal ganglia and cerebellum. Cognitive and functional disturbances alongside brain morphological changes in the impaired subgroup are consistent with a neurodevelopmental origin of psychosis. Our findings emphasize the relevance of tailored intervention early in the course of psychosis for patients suffering from the likely stronger neurodevelopmental character of the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wenzel, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Shalaila S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dwyer, Dominic B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruef, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Oeztuerk, Oemer Faruk UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonucci, Linda A. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Saldern, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonivento, Carolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Garzitto, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferro, Adele UNSPECIFIED UNSPECIFIED UNSPECIFIED Paolini, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Blautzik, Janusch UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgwardt, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Brambilla, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisenzahl, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Salokangas, Raimo K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Upthegrove, Rachel UNSPECIFIED orcid.org/0000-0001-8204-5103 UNSPECIFIED Wood, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED orcid.org/0000-0002-8988-3959 UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, Lana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603788
DOI:	10.1038/s41386-021-00963-1
Journal or Publication Title:	Neuropsychopharmacology
Volume:	46
Number:	8
Page Range:	S. 1475 - 1484
Date:	2021
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1740-634X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60378