Rauchmann, Boris-Stephan, Ersoezlue, Ersin, Stoecklein, Sophia, Keeser, Daniel ORCID: 0000-0002-0244-1024, Brosseron, Frederic, Buerger, Katharina, Dehent, Peter, Dobisch, Laura, Ertl-Wagner, Birgit, Fliessbach, Klaus, Haynes, John Dylan, Heneka, Michael T., Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Laake, Christoph, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Priller, Josef, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipl, Stefan, Tscheuschler, Maike, Vukovich, Ruth, Wagner, Michael ORCID: 0000-0003-2589-6440, Wiltfang, Jens, Yakupov, Renat, Duezel, Emrah, Jessen, Frank and Pernczky, Robert (2021). Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes. Cereb. Cortex, 31 (11). S. 4901 - 4916. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Several Alzheimer's disease (AD) atrophy subtypes were identified, but their brain network properties are unclear. We analyzed data from two independent datasets, including 166 participants (103 AD/63 controls) from the DZNE-longitudinal cognitive impairment and dementia study and 151 participants (121 AD/30 controls) from the AD neuroimaging initiative cohorts, aiming to identify differences between AD atrophy subtypes in resting-state functional magnetic resonance imaging intra-network connectivity (INC) and global and nodal network properties. Using a data-driven clustering approach, we identified four AD atrophy subtypes with differences in functional connectivity, accompanied by clinical and biomarker alterations, including a medio-temporal-predominant (S-MT), a limbic-predominant (S-L), a diffuse (S-D), and a mild-atrophy (S-MA) subtype. S-MT and S-D showed INC reduction in the default mode, dorsal attention, visual and limbic network, and a pronounced reduction of global efficiency and decrease of the clustering coefficient in parietal and temporal lobes. Despite severe atrophy in limbic areas, the S-L exhibited only marginal global network but substantial nodal network failure. S-MA, in contrast, showed limited impairment in clinical and cognitive scores but pronounced global network failure. Our results contribute toward a better understanding of heterogeneity in AD with the detection of distinct differences in functional connectivity networks accompanied by CSF biomarker and cognitive differences in AD subtypes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rauchmann, Boris-StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ersoezlue, ErsinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoecklein, SophiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keeser, DanielUNSPECIFIEDorcid.org/0000-0002-0244-1024UNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dehent, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ertl-Wagner, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynes, John DylanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Incesoy, Enise I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laake, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, Coraline D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munk, Matthias H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roy, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffler, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipl, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tscheuschler, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vukovich, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakupov, RenatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pernczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604272
DOI: 10.1093/cercor/bhab130
Journal or Publication Title: Cereb. Cortex
Volume: 31
Number: 11
Page Range: S. 4901 - 4916
Date: 2021
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1460-2199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUROPATHOLOGICALLY DEFINED SUBTYPES; FUNCTIONAL CONNECTIVITY; COMPOSITE SCORE; HYPOMETABOLISMMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60427

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