Universität zu Köln

Roberts, Stephen E., Morrison-Rees, Sian, Thapar, Nikhil ORCID: 0000-0002-0276-9951, Benninga, Marc A., Borrelli, Osvaldo, Broekaert, Ilse, Dolinsek, Jernej, Martin-de-Carpi, Javier, Mas, Emmanuel, Miele, Erasmo, Pienar, Corina, Ribes-Koninckx, Carmen, Thomassen, Rut A., Thomson, Mike, Tzivinikos, Christos, Thorne, Kymberley, John, Ann and Williams, John G. (2021). Systematic review and meta-analysis: the incidence and prevalence of paediatric coeliac disease across Europe. Aliment. Pharmacol. Ther., 54 (2). S. 109 - 129. HOBOKEN: WILEY. ISSN 1365-2036

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Abstract

Background Coeliac disease is one of the most prevalent immune-mediated gastrointestinal disorders in children. Aim To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis. Methods Systematic review and meta-analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. A total of 127 eligible studies were included. Results The prevalence of previously undiagnosed coeliac disease from screening surveys (histology based) ranged from 0.10% to 3.03% (median = 0.70%), with a significantly increasing annual trend (P = 0.029). Prevalence since 2000 was significantly higher in northern Europe (1.60%) than in eastern (0.98%), southern (0.69%) and western (0.60%) Europe. Large increases in the incidence of diagnosed coeliac disease across Europe have reached 50 per 100 000 person-years in Scandinavia, Finland and Spain. The median age at diagnosis increased from 1.9 years before 1990 to 7.6 since 2000. Larger increases in incidence were found in older age groups than in infants and ages Paediatric coeliac disease incidence and prevalence have risen across Europe and appear highest in Scandinavia, Finland and Spain. The most recent evidence shows large increases in incidence in most regions, but stabilisation in some (notably Sweden and Finland). Sharp increases in the age at diagnosis may reflect increases in milder and asymptomatic cases diagnosed since reliable serology testing became widely used, through endomysial antibodies after 1990 and tissue transglutaminase antibodies around 2000.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roberts, Stephen E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrison-Rees, Sian UNSPECIFIED UNSPECIFIED UNSPECIFIED Thapar, Nikhil UNSPECIFIED orcid.org/0000-0002-0276-9951 UNSPECIFIED Benninga, Marc A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borrelli, Osvaldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, Ilse UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolinsek, Jernej UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin-de-Carpi, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Mas, Emmanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Miele, Erasmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Pienar, Corina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribes-Koninckx, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomassen, Rut A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomson, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzivinikos, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Thorne, Kymberley UNSPECIFIED UNSPECIFIED UNSPECIFIED John, Ann UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, John G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-604583
DOI:	10.1111/apt.16337
Journal or Publication Title:	Aliment. Pharmacol. Ther.
Volume:	54
Number:	2
Page Range:	S. 109 - 129
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2036
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW INCIDENCE RATES; ANTIBODY-TEST; TISSUE TRANSGLUTAMINASE; CLINICAL PRESENTATION; DERMATITIS-HERPETIFORMIS; ANTIGLIADIN ANTIBODIES; CUMULATIVE INCIDENCE; DIAGNOSTIC-ACCURACY; DANISH POPULATION; RISING INCIDENCE Multiple languages Gastroenterology & Hepatology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60458