Universität zu Köln

Quhal, Fahad, Pradere, Benjamin, Sari Motlagh, Reza, Mori, Keiichiro, Laukhtina, Ekaterina, Aydh, Abdulmajeed, Mostafaei, Hadi ORCID: 0000-0001-5596-1771, Lysenko, Ivan, Schuettfort, Victor M., Stolzenbach, Franziska, Palumbo, Carlotta, Heidenreich, Axel, Briganti, Alberto, Karakiewicz, Pierre, I, Chlosta, Piotr and Shariat, Shahrokh F. (2021). Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer. Minerva Urol. Nephrol., 73 (5). S. 610 - 616. TURIN: EDIZIONI MINERVA MEDICA. ISSN 2724-6442

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Abstract

BACKGROUND: Serum albumin-to-globulin ratio (AGR) has been shown to be associated with poor prognosis in different malignancies. In this study we aimed to evaluate the predictive value of preoperative AGR for oncological outcomes in patients with radiation recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP) METHODS: A retrospective review of 214 consecutive patients with radiation recurrent PCa who underwent SRP at five referral centers. Levels of albumin and globulin were obtained before SRP and used to calculate the preoperativeAGR level. The optimal cut off value of preoperative AGR was 1.4. Univariable and multivariable Cox regression analyses were performed. RESULTS: Overall 89 (41.6%) patients had a low preoperative AGR. Low serum AGR was associated with biochemical recurrence (BCR) in univariable Cox regression analysis (HR 1.60, 95%CI 1.06-2.43, P=0.026). When adjusted for the effects of established preoperative and postoperative clinicopathologic confounders in different multivariable Cox regression models, this association did not retain its statistical significance. Moreover, preoperative AGR was not associated with metastasis free survival (P=0.21), overall survival (P=0.91) or cancer specific survival (P=0.61). CONCLUSIONS: In patients with radiation recurrent PCa undergoing SRP, low preoperativeAGR was associated with the risk of BCR only in univariable analysis. There was no association with metastasis or survival outcomes. Further studies are needed to evaluate this biomarker in the setting of primary PCa and to identify the patients most likely to benefit from a local

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Quhal, Fahad UNSPECIFIED UNSPECIFIED UNSPECIFIED Pradere, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sari Motlagh, Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Mori, Keiichiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukhtina, Ekaterina UNSPECIFIED UNSPECIFIED UNSPECIFIED Aydh, Abdulmajeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Mostafaei, Hadi UNSPECIFIED orcid.org/0000-0001-5596-1771 UNSPECIFIED Lysenko, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuettfort, Victor M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stolzenbach, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Palumbo, Carlotta UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Briganti, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Karakiewicz, Pierre, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Chlosta, Piotr UNSPECIFIED UNSPECIFIED UNSPECIFIED Shariat, Shahrokh F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-604821
DOI:	10.23736/S2724-6051.20.03938-7
Journal or Publication Title:	Minerva Urol. Nephrol.
Volume:	73
Number:	5
Page Range:	S. 610 - 616
Date:	2021
Publisher:	EDIZIONI MINERVA MEDICA
Place of Publication:	TURIN
ISSN:	2724-6442
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM MORTALITY; THERAPY; RADIOTHERAPY; INFLAMMATION; ADENOCARCINOMA; PROTEOME; FAILURE; BLOOD Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60482