Brooks, Jennifer D., Nabi, Hermann H., Andrulis, Irene L., Antoniou, Antonis C., Chiquette, Jocelyne, Despres, Philippe ORCID: 0000-0002-4163-7353, Devilee, Peter ORCID: 0000-0002-8023-2009, Dorval, Michel ORCID: 0000-0002-3207-8211, Droit, Arnaud ORCID: 0000-0001-7922-790X, Easton, Douglas F., Eisen, Andrea, Eloy, Laurence, Fienberg, Samantha, Goldgar, David, Hahnen, Eric, Joly, Yann, Knoppers, Bartha Maria, Lofters, Aisha, Masson, Jean-Yves, Mittmann, Nicole, Paquette, Jean-Sebastien ORCID: 0000-0002-9524-6761, Pashayan, Nora, Schmutzler, Rita, Stockley, Tracy ORCID: 0000-0002-4476-9722, Tavtigian, Sean, V, Walker, Meghan J., Wolfson, Michael, Chiarelli, Anna Maria and Simard, Jacques ORCID: 0000-0001-6906-3390 (2021). Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I). J. Pers. Med., 11 (6). BASEL: MDPI. ISSN 2075-4426

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Abstract

Early detection of breast cancer through screening reduces breast cancer mortality. The benefits of screening must also be considered within the context of potential harms (e.g., false positives, overdiagnosis). Furthermore, while breast cancer risk is highly variable within the population, most screening programs use age to determine eligibility. A risk-based approach is expected to improve the benefit-harm ratio of breast cancer screening programs. The PERSPECTIVE I&I (Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation) project seeks to improve personalized risk assessment to allow for a cost-effective, population-based approach to risk-based screening and determine best practices for implementation in Canada. This commentary describes the four inter-related activities that comprise the PERSPECTIVE I&I project. 1: Identification and validation of novel moderate to high-risk susceptibility genes. 2: Improvement, validation, and adaptation of a risk prediction web-tool for the Canadian context. 3: Development and piloting of a socio-ethical framework to support implementation of risk-based breast cancer screening. 4: Economic analysis to optimize the implementation of risk-based screening. Risk-based screening and prevention is expected to benefit all women, empowering them to work with their healthcare provider to make informed decisions about screening and prevention.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Brooks, Jennifer D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nabi, Hermann H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chiquette, JocelyneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Despres, PhilippeUNSPECIFIEDorcid.org/0000-0002-4163-7353UNSPECIFIED
Devilee, PeterUNSPECIFIEDorcid.org/0000-0002-8023-2009UNSPECIFIED
Dorval, MichelUNSPECIFIEDorcid.org/0000-0002-3207-8211UNSPECIFIED
Droit, ArnaudUNSPECIFIEDorcid.org/0000-0001-7922-790XUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisen, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eloy, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fienberg, SamanthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahnen, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joly, YannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoppers, Bartha MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lofters, AishaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Masson, Jean-YvesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mittmann, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paquette, Jean-SebastienUNSPECIFIEDorcid.org/0000-0002-9524-6761UNSPECIFIED
Pashayan, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stockley, TracyUNSPECIFIEDorcid.org/0000-0002-4476-9722UNSPECIFIED
Tavtigian, Sean, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, Meghan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfson, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chiarelli, Anna MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDorcid.org/0000-0001-6906-3390UNSPECIFIED
URN: urn:nbn:de:hbz:38-604893
DOI: 10.3390/jpm11060511
Journal or Publication Title: J. Pers. Med.
Volume: 11
Number: 6
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2075-4426
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RANDOMIZED NONINFERIORITY TRIAL; FUNCTIONAL-ANALYSIS; LIFETIME COSTS; PREDICTION; SUSCEPTIBILITY; TELEPHONE; BOADICEA; VARIANTS; MODEL; RECOMMENDATIONSMultiple languages
Health Care Sciences & Services; Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60489

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