Graeser, Monika ORCID: 0000-0003-1916-717X, Schrading, Simone, Gluz, Oleg, Strobel, Kevin, Herzog, Christopher, Umutlu, Lale, Frydrychowicz, Alex, Rjosk-Dendorfer, Dorothea, Wuerstlein, Rachel, Culemann, Ralph, Eulenburg, Christine, Adams, Jascha, Nitzsche, Henrik, Prange, Anna, Kuemmel, Sherko ORCID: 0000-0001-9355-494X, Grischke, Eva-Maria, Forstbauer, Helmut, Braun, Michael, Potenberg, Jochem, von Schumann, Raquel, Aktas, Bahriye ORCID: 0000-0002-5474-051X, Kolberg-Liedtke, Cornelia, Harbeck, Nadia, Kuhl, Christiane K. and Nitz, Ulrike (2021). Magnetic resonance imaging and ultrasound for prediction of residual tumor size in early breast cancer within the ADAPT subtrials. Breast Cancer Res., 23 (1). LONDON: BMC. ISSN 1465-542X

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Abstract

Background Prediction of histological tumor size by post-neoadjuvant therapy (NAT) ultrasound and magnetic resonance imaging (MRI) was evaluated in different breast cancer subtypes. Methods Imaging was performed after 12-week NAT in patients enrolled into three neoadjuvant WSG ADAPT subtrials. Imaging performance was analyzed for prediction of residual tumor measuring <= 10 mm and summarized using positive (PPV) and negative (NPV) predictive values. Results A total of 248 and 588 patients had MRI and ultrasound, respectively. Tumor size was over- or underestimated by < 10 mm in 4.4% and 21.8% of patients by MRI and in 10.2% and 15.8% by ultrasound. Overall, NPV (proportion of correctly predicted tumor size <= 10 mm) of MRI and ultrasound was 0.92 and 0.83; PPV (correctly predicted tumor size > 10 mm) was 0.52 and 0.61. MRI demonstrated a higher NPV and lower PPV than ultrasound in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-positive and in HR-/HER2+ tumors. Both methods had a comparable NPV and PPV in HR-/HER2- tumors. Conclusions In HR+/HER2+ and HR-/HER2+ breast cancer, MRI is less likely than ultrasound to underestimate while ultrasound is associated with a lower risk to overestimate tumor size. These findings may help to select the most optimal imaging approach for planning surgery after NAT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Graeser, MonikaUNSPECIFIEDorcid.org/0000-0003-1916-717XUNSPECIFIED
Schrading, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gluz, OlegUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strobel, KevinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herzog, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Umutlu, LaleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frydrychowicz, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rjosk-Dendorfer, DorotheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuerstlein, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Culemann, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eulenburg, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adams, JaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nitzsche, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prange, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuemmel, SherkoUNSPECIFIEDorcid.org/0000-0001-9355-494XUNSPECIFIED
Grischke, Eva-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forstbauer, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Potenberg, JochemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Schumann, RaquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aktas, BahriyeUNSPECIFIEDorcid.org/0000-0002-5474-051XUNSPECIFIED
Kolberg-Liedtke, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harbeck, NadiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhl, Christiane K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nitz, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604922
DOI: 10.1186/s13058-021-01413-y
Journal or Publication Title: Breast Cancer Res.
Volume: 23
Number: 1
Date: 2021
Publisher: BMC
Place of Publication: LONDON
ISSN: 1465-542X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60492

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