Universität zu Köln

Koninckx, Carmen Ribes, Donat, Ester ORCID: 0000-0002-0114-6445, Benninga, Marc A., Broekaert, Ilse J., Gottrand, Frederic, Kolho, Kaija-Leena, Lionetti, Paolo, Miele, Erasmo, Orel, Rok, Papadopoulou, Alexandra, Pienar, Corina, Schappi, Michela G., Wilschanski, Michael and Thapar, Nikhil (2021). The Use of Fecal Calprotectin Testing in Paediatric Disorders: A Position Paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology Committee. J. Pediatr. Gastroenterol. Nutr., 72 (4). S. 617 - 641. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4801

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Abstract

Objectives: The aim of the study was to review the evidence regarding the clinical use and value of fecal calprotectin (FC) measurements in different gastrointestinal disorders in children. Methods: A literature search was conducted in the PubMed, MEDLINE, EMBASE, and Cochrane databases until October 31, 2019. Subtopics were identified and each assigned to individual authors. Results: A total of 28 recommendations were voted on using the nominal voting technique. Recommendations are given related to sampling, measurement methods, and results interpretation. The 14 authors anonymously voted on each recommendation using a 9-point scale (1 strongly disagree to 9 fully agree). Consensus was considered achieved if at least 75% of the authors voted 6, 7, 8, or 9. Conclusions: Consensus was reached for all recommendations. Limitations for the use of FC in clinical practice include variability in extraction methodology, performance of test kits as well as the need to establish local reference ranges because of the influence of individual factors, such as age, diet, microbiota, and drugs. The main utility of FC measurement at present is in the diagnosis and monitoring of inflammatory bowel disease (IBD) as well as to differentiate it from functional gastrointestinal disorders (FAPDs). FC, however, has neither utility in the diagnosis of infantile colic nor to differentiate between functional and organic constipation. A rise in FC concentration, may alert to the risk of developing necrotizing enterocolitis and help identifying gastrointestinal involvement in children with Henoch-Schonlein purpura. FC measurement is of little value in Cow's Milk Protein Allergy, coeliac disease (CD), and cystic fibrosis. FC does neither help to distinguish bacterial from viral acute gastroenteritis (AGE), nor to diagnose Helicobacter Pylori infection, small intestinal bacterial overgrowth (SIBO), acute appendicitis (AA), or intestinal polyps.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koninckx, Carmen Ribes UNSPECIFIED UNSPECIFIED UNSPECIFIED Donat, Ester UNSPECIFIED orcid.org/0000-0002-0114-6445 UNSPECIFIED Benninga, Marc A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, Ilse J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottrand, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolho, Kaija-Leena UNSPECIFIED UNSPECIFIED UNSPECIFIED Lionetti, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Miele, Erasmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Orel, Rok UNSPECIFIED UNSPECIFIED UNSPECIFIED Papadopoulou, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Pienar, Corina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schappi, Michela G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilschanski, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Thapar, Nikhil UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-605036
DOI:	10.1097/MPG.0000000000003046
Journal or Publication Title:	J. Pediatr. Gastroenterol. Nutr.
Volume:	72
Number:	4
Page Range:	S. 617 - 641
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4801
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFLAMMATORY-BOWEL-DISEASE; FUNCTIONAL GASTROINTESTINAL DISORDERS; EXCLUSIVE ENTERAL NUTRITION; PROTON PUMP INHIBITORS; C-REACTIVE PROTEIN; INTESTINAL INFLAMMATION; CROHNS-DISEASE; ULCERATIVE-COLITIS; ACUTE APPENDICITIS; CYSTIC-FIBROSIS Multiple languages Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60503