Universität zu Köln

van Wamelen, Daniel J., Sauerbier, Anna, Leta, Valentina, Rodriguez-Blazquez, Carmen, Falup-Pecurariu, Cristian, Rodriguez-Violante, Mayela, Rizos, Alexandra, Tsuboi, Y., Metta, Vinod, Bhidayasiri, Roongroj, Bhattacharya, Kalyan, Borgohain, Rupam, Prashanth, L. K., Rosales, Raymond, Lewis, Simon, Fung, Victor, Behari, Madhuri, Goyal, Vinay, Kishore, Asha, Lloret, Santiago Perez, Martinez-Martin, Pablo and Chaudhuri, K. Ray (2021). Cross-sectional analysis of the Parkinson's disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life. Sci Rep, 11 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

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Abstract

Growing evidence suggests that non-motor symptoms (NMS) in Parkinson's disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naive and non-drug-naive treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 +/- 10.8 years, mean disease duration 6.3 +/- 5.6 years, median Hoehn and Yahr stage was 2 (2-3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 +/- 37.2. Differences in non-motor burden and patterns differed significantly between drug-naive participants, those with a disease duration of less than five years, and those with a duration of five years or over (p <= 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 +/- 36.3; Americas: 55.3 +/- 42.8; Asia: 26.6 +/- 25.1; p<0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p<less than or equal to>0.020). The best predictor of quality of life was the mood/apathy domain (beta =0.308, p<0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Wamelen, Daniel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbier, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Leta, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez-Blazquez, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Falup-Pecurariu, Cristian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez-Violante, Mayela UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsuboi, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Metta, Vinod UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhidayasiri, Roongroj UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhattacharya, Kalyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgohain, Rupam UNSPECIFIED UNSPECIFIED UNSPECIFIED Prashanth, L. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosales, Raymond UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Fung, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Behari, Madhuri UNSPECIFIED UNSPECIFIED UNSPECIFIED Goyal, Vinay UNSPECIFIED UNSPECIFIED UNSPECIFIED Kishore, Asha UNSPECIFIED UNSPECIFIED UNSPECIFIED Lloret, Santiago Perez UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-605423
DOI:	10.1038/s41598-021-88651-4
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYMPTOMS SCALE; RATING-SCALE; PREVALENCE; PROGRESSION; COHORT; MULTICENTER; DISABILITY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60542