Aigner, Felix, Siegel, Robert, Werner, Ricardo N., Esser, Stefan, Oette, Mark, Weyandt, Gerhard, Kahlke, Volker, Saeed, Adal, Turina, Matthias, Mosthaf, Franz A., Dresel, Stefan, Simon, Steffen, Niedobitek, Gerald, Koswig, Stephan, Budach, Volker, Schmielau, Jan, Raab, Hans-Rudolf, Faber, Gerhard, Senf, Bianca, Roedel, Claus, Fokas, E., Mahlberg, Rolf, Steingraeber, Maria, Wessling, Johannes, Wieland, Ulrike, Fuerst, Alois, Lugger, Petra, Prott, Franz-Josef, Kronberger, Irmgard, Baumeler, Stephan, Maurus, Christine, Grohmann, Erich, Gaskins, Matthew, Valle, Gabriela L. Avila and Dittmann, Martin (2021). S3 guideline anal carcinoma Diagnostics, therapy and follow-up of anal canal and anal margin carcinomas. Coloproctology, 43 (3). S. 150 - 217. NEW YORK: SPRINGER. ISSN 1615-6730

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Abstract

Anal cancer is a relatively rare tumor but has shown a continuous increase of new diseases with a doubling of the incidence in the last 20 years. Nearly all anal cancers are induced by a persisting infection with human papillomavirus (HPV). In the guidelines program for oncology for the first time German language S3 guidelines for optimization of the diagnostics, treatment and aftercare of anal cancer have been compiled under the patronage of the German Society of Coloproctology. Suggestions for recommendations were compiled in interdisciplinary working groups based on the formulated key questions, which were modified and graded within a nominal consensus procedure. After the systematic literature search the endpoint-related assessment and classification of the evidence was carried out within the framework of the GRADE procedure. A total of 93 recommendations and statements were formulated with respect to the topics prevention and screening, diagnostics and staging, supportive measures before and after targeted tumor treatment, treatment of anal cancer in stages I-III, response evaluation following primary chemoradiotherapy, aftercare, treatment of residual and recurrent anal cancer, treatment of metastatic anal cancer (stage IV), palliative care and rehabilitation. The new guidelines provide a foundation for the optimization of interdisciplinary and cross-sectoral care of anal cancer patients. Based on quality indicators future health services research should investigate whether the guideline recommendations are taken into consideration and whether these contribute to an improvement in care.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Aigner, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegel, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, Ricardo N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esser, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oette, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyandt, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahlke, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saeed, AdalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turina, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosthaf, Franz A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dresel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niedobitek, GeraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koswig, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Budach, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmielau, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raab, Hans-RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faber, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Senf, BiancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roedel, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokas, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahlberg, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steingraeber, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wessling, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieland, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuerst, AloisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lugger, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prott, Franz-JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kronberger, IrmgardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumeler, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maurus, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grohmann, ErichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaskins, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valle, Gabriela L. AvilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dittmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605618
DOI: 10.1007/s00053-021-00530-8
Journal or Publication Title: Coloproctology
Volume: 43
Number: 3
Page Range: S. 150 - 217
Date: 2021
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1615-6730
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SQUAMOUS-CELL-CARCINOMA; SALVAGE ABDOMINOPERINEAL RESECTION; POSITRON-EMISSION-TOMOGRAPHY; HUMAN-PAPILLOMAVIRUS INFECTION; CLINICAL-PRACTICE GUIDELINES; MODULATED RADIATION-THERAPY; QUALITY-OF-LIFE; HIV-UNINFECTED INDIVIDUALS; QUADRIVALENT HPV VACCINE; FDG-PET PARAMETERSMultiple languages
Gastroenterology & HepatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60561

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