Penzel, Nora, Antonucci, Linda A., Betz, Linda T. ORCID: 0000-0003-1741-4069, Sanfelici, Rachele, Weiske, Johanna, Pogarell, Oliver, Cumming, Paul, Quednow, Boris B. ORCID: 0000-0001-7933-2865, Howes, Oliver, Falkai, Peter, Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Rosen, Marlene, Haidl, Theresa, Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Salokangas, Raimo R. K., Pantelis, Christos ORCID: 0000-0002-9565-0238, Wood, Stephen J., Koutsouleris, Nikolaos and Kambeitz, Joseph ORCID: 0000-0002-8988-3959 (2021). Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis. Neuropsychopharmacology, 46 (8). S. 1484 - 1494. LONDON: SPRINGERNATURE. ISSN 1740-634X

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Abstract

Cannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, this results from detrimental effects of early cannabis use on brain maturation during this vulnerable period. However, studies investigating the interaction between early cannabis use and brain structural alterations hitherto reported inconclusive findings. We investigated effects of age of cannabis initiation on psychosis using data from the multicentric Personalized Prognostic Tools for Early Psychosis Management (PRONIA) and the Cannabis Induced Psychosis (CIP) studies, yielding a total sample of 102 clinically-relevant cannabis users with recent onset psychosis. GM covariance underlies shared maturational processes. Therefore, we performed source-based morphometry analysis with spatial constraints on structural brain networks showing significant alterations in schizophrenia in a previous multisite study, thus testing associations of these networks with the age of cannabis initiation and with confounding factors. Earlier cannabis initiation was associated with more severe positive symptoms in our cohort. Greater gray matter volume (GMV) in the previously identified cerebellar schizophrenia-related network had a significant association with early cannabis use, independent of several possibly confounding factors. Moreover, GMV in the cerebellar network was associated with lower volume in another network previously associated with schizophrenia, comprising the insula, superior temporal, and inferior frontal gyrus. These findings are in line with previous investigations in healthy cannabis users, and suggest that early initiation of cannabis perturbs the developmental trajectory of certain structural brain networks in a manner imparting risk for psychosis later in life.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Penzel, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonucci, Linda A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Betz, Linda T.UNSPECIFIEDorcid.org/0000-0003-1741-4069UNSPECIFIED
Sanfelici, RacheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiske, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pogarell, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cumming, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quednow, Boris B.UNSPECIFIEDorcid.org/0000-0001-7933-2865UNSPECIFIED
Howes, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Bertolino, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencer, RebekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haidl, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo R. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDorcid.org/0000-0002-9565-0238UNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDorcid.org/0000-0002-8988-3959UNSPECIFIED
URN: urn:nbn:de:hbz:38-605628
DOI: 10.1038/s41386-021-00977-9
Journal or Publication Title: Neuropsychopharmacology
Volume: 46
Number: 8
Page Range: S. 1484 - 1494
Date: 2021
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1740-634X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SOURCE-BASED MORPHOMETRY; 1ST EPISODE PSYCHOSIS; CLINICAL HIGH-RISK; GREY-MATTER; MARIJUANA USE; BRAIN; USERS; SCHIZOPHRENIA; ABNORMALITIES; ADOLESCENTSMultiple languages
Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60562

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