Universität zu Köln

Orr, Jeremy E. ORCID: 0000-0002-4498-5337, Ayappa, Indu, Eckert, Danny J., Feldman, Jack L., Jackson, Chandra L., Javaheri, Shahrokh, Khayat, Rami N., Martin, Jennifer L., Mehra, Reena, Naughton, Matthew T., Randerath, Winfried J., Sands, Scott A., Somers, Virend K. and Badr, M. Safwan (2021). Research Priorities for Patients with Heart Failure and Central Sleep Apnea An Official American Thoracic Society Research Statement. Am. J. Respir. Crit. Care Med., 203 (6). S. E11 - 14. NEW YORK: AMER THORACIC SOC. ISSN 1535-4970

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Abstract

Background: Central sleep apnea (CSA) is common among patients with heart failure and has been strongly linked to adverse outcomes. However, progress toward improving outcomes for such patients has been limited. The purpose of this official statement from the American Thoracic Society is to identify key areas to prioritize for future research regarding CSA in heart failure. Methods: An international multidisciplinary group with expertise in sleep medicine, pulmonary medicine, heart failure, clinical research, and health outcomes was convened. The group met at the American Thoracic Society 2019 International Conference to determine research priority areas. A statement summarizing the findings of the group was subsequently authored using input from all members. Results: The workgroup identified 11 specific research priorities in several key areas: 1) control of breathing and pathophysiology leading to CSA, 2) variability across individuals and over time, 3) techniques to examine CSA pathogenesis and outcomes, 4) impact of device and pharmacological treatment, and 5) implementing CSA treatment for all individuals Conclusions: Advancing care for patients with CSA in the context of heart failure will require progress in the arenas of translational (basic through clinical), epidemiological, and patient-centered outcome research. Given the increasing prevalence of heart failure and its associated substantial burden to individuals, society, and the healthcare system, targeted research to improve knowledge of CSA pathogenesis and treatment is a priority.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Orr, Jeremy E. UNSPECIFIED orcid.org/0000-0002-4498-5337 UNSPECIFIED Ayappa, Indu UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckert, Danny J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldman, Jack L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jackson, Chandra L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Javaheri, Shahrokh UNSPECIFIED UNSPECIFIED UNSPECIFIED Khayat, Rami N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Jennifer L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehra, Reena UNSPECIFIED UNSPECIFIED UNSPECIFIED Naughton, Matthew T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, Winfried J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sands, Scott A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Somers, Virend K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Badr, M. Safwan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-605755
DOI:	10.1164/rccm.202101-0190ST
Journal or Publication Title:	Am. J. Respir. Crit. Care Med.
Volume:	203
Number:	6
Page Range:	S. E11 - 14
Date:	2021
Publisher:	AMER THORACIC SOC
Place of Publication:	NEW YORK
ISSN:	1535-4970
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEYNE-STOKES RESPIRATION; POSITIVE AIRWAY PRESSURE; ADAPTIVE SERVO-VENTILATION; CARDIAC RESYNCHRONIZATION THERAPY; CAPILLARY WEDGE PRESSURE; CARBON-DIOXIDE; SYMPATHETIC ACTIVITY; INCREASED PROPENSITY; LOOP GAIN; PREVALENCE Multiple languages Critical Care Medicine; Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60575