Valerio, Luca ORCID: 0000-0003-4466-0724, Barco, Stefano ORCID: 0000-0002-2618-347X, Jankowski, Marius, Rosenkranz, Stephan, Lankeit, Mareike ORCID: 0000-0001-5211-7997, Held, Matthias, Gerhardt, Felix, Bruch, Leonhard, Ewert, Ralf, Faehling, Martin, Freise, Julia, Ghofrani, Hossein-Ardeschir, Gruenig, Ekkehard, Halank, Michael, Hoeper, Marius M., Klok, Frederikus A., Leuchte, Hanno H., Mayer, Eckhard, Meyer, F. Joachim, Neurohr, Claus, Opitz, Christian, Schmidt, Kai-Helge, Seyfarth, Hans-Juergen, Trudzinski, Franziska, Wachter, Rolf, Wilkens, Heinrike, Wild, Philipp S. and Konstantinides, Stavros, V (2021). Quality of Life 3 and 12 Months Following Acute Pulmonary Embolism Analysis From a Prospective Multicenter Cohort Study. Chest, 159 (6). S. 2428 - 2439. AMSTERDAM: ELSEVIER. ISSN 1931-3543

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Abstract

BACKGROUND: Few data are available on the long-term course and predictors of quality of life (QoL) following acute pulmonary embolism (PE). RESEARCH QUESTION: What are the kinetics and determinants of disease-specific and generic health-related QoL 3 and 12 months following an acute PE? STUDY DESIGN AND METHODS: The Follow-up after Acute Pulmonary Embolism (FOCUS) study prospectively followed up consecutive adult patients with objectively diagnosed PE. Patients were considered for study who completed the Pulmonary Embolism Quality of Life (PEmb-QoL) questionnaire at predefined visits 3 and 12 months following PE. The course of disease-specific QoL as assessed using the PEmb-QoL and the impact of baseline characteristics using multivariable mixed effects linear regression were studied; also assessed was the course of generic QoL as evaluated by using the EuroQoL Group 5-Dimension 5-Level utility index and the EuroQoL Visual Analog Scale. RESULTS: In 620 patients (44% women; median age, 62 years), overall disease-specific QoL improved from 3 to 12 months, with a decrease in the median PEmb-QoL score from 19.4% to 13.0% and a mean individual change of -4.3% (95% CI, -3.2 to -5.5). Female sex, cardiopulmonary disease, and higher BMI were associated with worse QoL at both 3 and 12 months. Over time, the association with BMI became weaker, whereas older age and previous VTE were associated with worsening QoL. Generic QoL also improved: the mean +/- SD EuroQoL Group 5-Dimension 5-Level utility index increased from 0.85 +/- 0.22 to 0.87 +/- 0.20 and the visual analog scale from 72.9 +/- 18.8 to 74.4 +/- 19.1. INTERPRETATION: In a large cohort of survivors of acute PE, the change of QoL was quantified between months 3 and 12 following diagnosis, and factors independently associated with lower QoL and slower recovery of QoL were identified. This information may facilitate the planning and interpretation of clinical trials assessing QoL and help guide patient management.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Valerio, LucaUNSPECIFIEDorcid.org/0000-0003-4466-0724UNSPECIFIED
Barco, StefanoUNSPECIFIEDorcid.org/0000-0002-2618-347XUNSPECIFIED
Jankowski, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenkranz, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lankeit, MareikeUNSPECIFIEDorcid.org/0000-0001-5211-7997UNSPECIFIED
Held, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerhardt, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruch, LeonhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewert, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faehling, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freise, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghofrani, Hossein-ArdeschirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruenig, EkkehardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halank, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoeper, Marius M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klok, Frederikus A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leuchte, Hanno H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer, EckhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, F. JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neurohr, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opitz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Kai-HelgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seyfarth, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trudzinski, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachter, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilkens, HeinrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wild, Philipp S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konstantinides, Stavros, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605832
DOI: 10.1016/j.chest.2021.01.071
Journal or Publication Title: Chest
Volume: 159
Number: 6
Page Range: S. 2428 - 2439
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1931-3543
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OUTCOMES; GUIDELINES; MANAGEMENTMultiple languages
Critical Care Medicine; Respiratory SystemMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60583

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