Freudenhammer, Mirjam ORCID: 0000-0002-3208-2747, Karampatsas, Konstantinos, Le Doare, Kirsty, Lander, Fabian, Armann, Jakob, Acero Moreno, Daniel, Boyle, Margaret, Buxmann, Horst, Campbell, Ruth, Chalker, Victoria, Cunney, Robert, Doherty, Lorraine, Davies, Eleri, Efstratiou, Androulla, Elling, Roland, Endmann, Matthias ORCID: 0000-0002-1769-7348, Essers, Jochen, Hentschel, Roland, Jones, Christine E., Kallsen, Steffen, Kapatai, Georgia, Kruger, Marcus, Ladhani, Shamez, Lamagni, Theresa, Lindsay, Diane, Meehan, Mary, O'Sullivan, Catherine P., Patel, Darshana, Reynolds, Arlene J., Roll, Claudia, Schulzke, Sven, Smith, Andrew, Stein, Anja, von der Wense, Axel, Voss, Egbert, Wieg, Christian, Hartel, Christoph, Heath, Paul T. and Henneke, Philipp (2021). Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis. Front. Immunol., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

Group B Streptococcus (GBS) is a common intestinal colonizer during the neonatal period, but also may cause late-onset sepsis or meningitis in up to 0.5% of otherwise healthy colonized infants after day 3 of life. Transmission routes and risk factors of this late-onset form of invasive GBS disease (iGBS) are not fully understood. Cases of iGBS with recurrence (n=25) and those occurring in parallel in twins/triplets (n=32) from the UK and Ireland (national surveillance study 2014/15) and from Germany and Switzerland (retrospective case collection) were analyzed to unravel shared (in affected multiples) or fixed (in recurrent disease) risk factors for GBS disease. The risk of iGBS among infants from multiple births was high (17%), if one infant had already developed GBS disease. The interval of onset of iGBS between siblings was 4.5 days and in recurrent cases 12.5 days. Disturbances of the individual microbiome, including persistence of infectious foci are suggested e.g. by high usage of perinatal antibiotics in mothers of affected multiples, and by the association of an increased risk of recurrence with a short term of antibiotics [aOR 4.2 (1.3-14.2), P=0.02]. Identical GBS serotypes in both recurrent infections and concurrently infected multiples might indicate a failed microbiome integration of GBS strains that are generally regarded as commensals in healthy infants. The dynamics of recurrent GBS infections or concurrent infections in multiples suggest individual patterns of exposure and fluctuations in host immunity, causing failure of natural niche occupation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Freudenhammer, MirjamUNSPECIFIEDorcid.org/0000-0002-3208-2747UNSPECIFIED
Karampatsas, KonstantinosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Doare, KirstyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lander, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Armann, JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Acero Moreno, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boyle, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buxmann, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chalker, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cunney, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doherty, LorraineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davies, EleriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Efstratiou, AndroullaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elling, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Endmann, MatthiasUNSPECIFIEDorcid.org/0000-0002-1769-7348UNSPECIFIED
Essers, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hentschel, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, Christine E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kallsen, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kapatai, GeorgiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruger, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ladhani, ShamezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamagni, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindsay, DianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meehan, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Sullivan, Catherine P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, DarshanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reynolds, Arlene J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roll, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulzke, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von der Wense, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voss, EgbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieg, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartel, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heath, Paul T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henneke, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606046
DOI: 10.3389/fimmu.2021.617925
Journal or Publication Title: Front. Immunol.
Volume: 12
Date: 2021
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1664-3224
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GUT MICROBIOME; COLONIZATION; INTRAPARTUM; INFANTS; ANTIBIOTICS; PROPHYLAXIS; RESISTANCE; PRETERMMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60604

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