Bonthuis, Marjolein, Vidal, Enrico ORCID: 0000-0003-3963-0803, Bjerre, Anna, Aydog, Ozlem, Baiko, Sergey, Garneata, Liliana, Guzzo, Isabella, Heaf, James G., Jahnukainen, Timo, Lilien, Marc, Mallett, Tamara, Mirescu, Gabriel, Mochanova, Elena A., Nuesken, Eva, Rascher, Katherine, Roussinov, Dimitar, Szczepanska, Maria ORCID: 0000-0002-6772-1983, Tsimaratos, Michel ORCID: 0000-0001-6027-0721, Varvara, Askiti, Verrina, Enrico, Veselinovic, Bojana, Jager, Kitty J. and Harambat, Jerome (2021). Ten-year trends in epidemiology and outcomes of pediatric kidney replacement therapy in Europe: data from the ESPN/ERA-EDTA Registry. Pediatr. Nephrol., 36 (8). S. 2337 - 2349. NEW YORK: SPRINGER. ISSN 1432-198X

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Abstract

Background For 10 consecutive years, the ESPN/ERA-EDTA Registry has included data on children with stage 5 chronic kidney disease (CKD 5) receiving kidney replacement therapy (KRT) in Europe. We examined trends in incidence and prevalence of KRT and patient survival. Methods We included all children aged <15 years starting KRT 2007-2016 in 22 European countries participating in the ESPN/ERA-EDTA Registry since 2007. General population statistics were derived from Eurostat. Incidence and prevalence were expressed per million age-related population (pmarp) and time trends studied with JoinPoint regression. We analyzed survival trends using Cox regression. Results Incidence of children commencing KRT <15 years remained stable over the study period, varying between 5.5 and 6.6 pmarp. Incidence by treatment modality was unchanged over time: 2.0 for hemodialysis (HD) and peritoneal dialysis (PD) and 1.0 for transplantation. Prevalence increased in all age categories and overall rose 2% annually from 26.4 pmarp in 2007 to 32.1 pmarp in 2016. Kidney transplantation prevalence increased 5.1% annually 2007-2009, followed by 1.5% increase/year until 2016. Prevalence of PD steadily increased 1.4% per year over the entire period, and HD prevalence started increasing 6.1% per year from 2011 onwards. Five-year unadjusted patient survival on KRT was around 94% and similar for those initiating KRT 2007-2009 or 2010-2012 (adjusted HR: 0.98, 95% CI:0.71-1.35). Conclusions We found a stable incidence and increasing prevalence of European children on KRT 2007-2016. Five-year patient survival was good and was unchanged over time. These data can inform patients and healthcare providers and aid health policy makers on future resource planning of pediatric KRT in Europe.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bonthuis, MarjoleinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, EnricoUNSPECIFIEDorcid.org/0000-0003-3963-0803UNSPECIFIED
Bjerre, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aydog, OzlemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baiko, SergeyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garneata, LilianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guzzo, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heaf, James G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jahnukainen, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lilien, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallett, TamaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mirescu, GabrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mochanova, Elena A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuesken, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rascher, KatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roussinov, DimitarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szczepanska, MariaUNSPECIFIEDorcid.org/0000-0002-6772-1983UNSPECIFIED
Tsimaratos, MichelUNSPECIFIEDorcid.org/0000-0001-6027-0721UNSPECIFIED
Varvara, AskitiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verrina, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veselinovic, BojanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jager, Kitty J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harambat, JeromeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606185
DOI: 10.1007/s00467-021-04928-w
Journal or Publication Title: Pediatr. Nephrol.
Volume: 36
Number: 8
Page Range: S. 2337 - 2349
Date: 2021
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-198X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Pediatrics; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60618

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