Berkell, Matilda ORCID: 0000-0002-7096-7896, Mysara, Mohamed ORCID: 0000-0001-5746-4330, Xavier, Basil Britto ORCID: 0000-0002-5897-0240, van Werkhoven, Cornelis H., Monsieurs, Pieter, Lammens, Christine, Ducher, Annie, Vehreschild, Maria J. G. T., Goossens, Herman, de Gunzburg, Jean ORCID: 0000-0001-8049-9283, Bonten, Marc J. M., Malhotra-Kumar, Surbhi, Engbers, Annemarie, de Regt, Marieke, Biehl, Lena M., Cornely, Oliver A., Jazmati, Nathalie, Bouverne, Marie-Noelle, Sablier-Gallis, Frederique, Mentre, France, Merle, Uta, Stallmach, Andreas, Rupp, Jan ORCID: 0000-0001-8722-1233, Bogner, Johannes, Lubbert, Christoph, Silling, Gerda, Witzke, Oliver, Gikas, Achilleas, Maraki, Sofia, Daikos, George, Tsiodras, Sotirios, Skoutelis, Athanasios, Sambatakou, Helen, Pujol, Miguel, Dominguez-Luzon, M. Angeles, Aguado, Jose M., Bouza, Emilio, Cobo, Javier, Rodriguez-Bano, Jesus ORCID: 0000-0001-6732-9001, Almirante, Benito, Cisneros, Julian de la Torre, Florescu, Simin A., Nica, Maria, Vata, Andrei, Hristea, Adriana, Lupse, Mihaela, Herghea, Delia, Postil, Deborah, Barraud, Olivier, Molina, Jean-Michel, De Lastours, Victoire, Guimard, Thomas, Talarmin, Jean-Philippe, Duval, Xavier, Bernard, Louis and Launay, Odile (2021). Microbiota-based markers predictive of development of Clostridioides difficile infection. Nat. Commun., 12 (1). BERLIN: NATURE RESEARCH. ISSN 2041-1723

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Abstract

Antibiotic-induced modulation of the intestinal microbiota can lead to Clostridioides difficile infection (CDI), which is associated with considerable morbidity, mortality, and healthcare-costs globally. Therefore, identification of markers predictive of CDI could substantially contribute to guiding therapy and decreasing the infection burden. Here, we analyze the intestinal microbiota of hospitalized patients at increased CDI risk in a prospective, 90-day cohort-study before and after antibiotic treatment and at diarrhea onset. We show that patients developing CDI already exhibit significantly lower diversity before antibiotic treatment and a distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients. We find that antibiotic treatment-induced dysbiosis is class-specific with beta-lactams further increasing enterococcal abundance. Our findings, validated in an independent prospective patient cohort developing CDI, can be exploited to enrich for high-risk patients in prospective clinical trials, and to develop predictive microbiota-based diagnostics for management of patients at risk for CDI.Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patients from 34 hospitals in 6 different European countries and show distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Berkell, MatildaUNSPECIFIEDorcid.org/0000-0002-7096-7896UNSPECIFIED
Mysara, MohamedUNSPECIFIEDorcid.org/0000-0001-5746-4330UNSPECIFIED
Xavier, Basil BrittoUNSPECIFIEDorcid.org/0000-0002-5897-0240UNSPECIFIED
van Werkhoven, Cornelis H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monsieurs, PieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammens, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ducher, AnnieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goossens, HermanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Gunzburg, JeanUNSPECIFIEDorcid.org/0000-0001-8049-9283UNSPECIFIED
Bonten, Marc J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malhotra-Kumar, SurbhiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engbers, AnnemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Regt, MariekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biehl, Lena M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jazmati, NathalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bouverne, Marie-NoelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sablier-Gallis, FrederiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mentre, FranceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merle, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stallmach, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rupp, JanUNSPECIFIEDorcid.org/0000-0001-8722-1233UNSPECIFIED
Bogner, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lubbert, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silling, GerdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witzke, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gikas, AchilleasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maraki, SofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daikos, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsiodras, SotiriosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skoutelis, AthanasiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sambatakou, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pujol, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominguez-Luzon, M. AngelesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aguado, Jose M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bouza, EmilioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cobo, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Bano, JesusUNSPECIFIEDorcid.org/0000-0001-6732-9001UNSPECIFIED
Almirante, BenitoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cisneros, Julian de la TorreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Florescu, Simin A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nica, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vata, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hristea, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lupse, MihaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herghea, DeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Postil, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barraud, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molina, Jean-MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Lastours, VictoireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guimard, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Talarmin, Jean-PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duval, XavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernard, LouisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Launay, OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607796
DOI: 10.1038/s41467-021-22302-0
Journal or Publication Title: Nat. Commun.
Volume: 12
Number: 1
Date: 2021
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60779

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