Buffenstein, Rochelle, Amoroso, Vincent, Andziak, Blazej, Avdieiev, Stanislav, Azpurua, Jorge, Barker, Alison J., Bennett, Nigel C., Brieno-Enriquez, Miguel A., Bronner, Gary N., Coen, Clive ORCID: 0000-0003-1303-216X, Delaney, Martha A., Dengler-Crish, Christine M., Edrey, Yael H., Faulkes, Chris G., Frankel, Daniel, Friedlander, Gerard, Gibney, Patrick A., Gorbunova, Vera, Hine, Christopher, Holmes, Melissa M., Jarvis, Jennifer U. M., Kawamura, Yoshimi ORCID: 0000-0002-9864-7974, Kutsukake, Nobuyuki, Kenyon, Cynthia, Khaled, Walid T., Kikusui, Takefumi, Kissil, Joseph, Lagestee, Samantha, Larson, John, Lauer, Amanda, Lavrenchenko, Leonid A., Lee, Angela, Levitt, Jonathan B., Lewin, Gary R., Hardell, Kaitlyn N. Lewis, Lin, Tzu Hua D., Mason, Matthew J., McCloskey, Dan ORCID: 0000-0003-3596-8014, McMahon, Mary ORCID: 0000-0001-5548-2949, Miura, Kyoko ORCID: 0000-0003-2208-149X, Mogi, Kazutaka, Narayan, Vikram, O'Connor, Timothy P., Okanoya, Kazuo, O'Riain, M. Justin, Park, Thomas J., Place, Ned J., Podshivalova, Katie, Pamenter, Matthew E., Pyott, Sonja J., Reznick, Jane, Ruby, J. Graham, Salmon, Adam B., Santos-Sacchi, Joseph, Sarko, Diana K., Seluanov, Andrei, Shepard, Alyssa, Smith, Megan, Storey, Kenneth B., Tian, Xiao, Vice, Emily N., Viltard, Melanie, Watarai, Akiyuki, Wywial, Ewa, Yamakawa, Masanori ORCID: 0000-0002-4120-8874, Zemlemerova, Elena D., Zions, Michael and Smith, Ewan St John (2022). The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology. Biol. Rev., 97 (1). S. 115 - 141. HOBOKEN: WILEY. ISSN 1469-185X

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Abstract

The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinary longevity, but also because of unusual protective features (e.g. its tolerance of variable oxygen availability), which may be pertinent to several human disease states, including ischemia/reperfusion injury and neurodegeneration. A recent article entitled 'Surprisingly long survival of premature conclusions about naked mole-rat biology' described 28 'myths' which, those authors claimed, are a 'perpetuation of beautiful, but falsified, hypotheses' and impede our understanding of this enigmatic mammal. Here, we re-examine each of these 'myths' based on evidence published in the scientific literature. Following Braude et al., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) 'myths' that are based on incomplete understanding, where more evidence is clearly needed; (iii) 'myths' where the accumulation of evidence over the years has led to a revision in interpretation, but where there is no significant disagreement among scientists currently working in the field; (iv) 'myths' where there is a genuine difference in opinion among active researchers, based on alternative interpretations of the available evidence. The term 'myth' is particularly inappropriate when applied to competing, evidence-based hypotheses, which form part of the normal evolution of scientific knowledge. Here, we provide a comprehensive critical review of naked mole-rat biology and attempt to clarify some of these misconceptions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Buffenstein, RochelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amoroso, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andziak, BlazejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Avdieiev, StanislavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azpurua, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barker, Alison J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bennett, Nigel C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brieno-Enriquez, Miguel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bronner, Gary N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coen, CliveUNSPECIFIEDorcid.org/0000-0003-1303-216XUNSPECIFIED
Delaney, Martha A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dengler-Crish, Christine M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edrey, Yael H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faulkes, Chris G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frankel, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedlander, GerardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibney, Patrick A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gorbunova, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hine, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmes, Melissa M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarvis, Jennifer U. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kawamura, YoshimiUNSPECIFIEDorcid.org/0000-0002-9864-7974UNSPECIFIED
Kutsukake, NobuyukiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kenyon, CynthiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khaled, Walid T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kikusui, TakefumiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kissil, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagestee, SamanthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larson, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lauer, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lavrenchenko, Leonid A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levitt, Jonathan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewin, Gary R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hardell, Kaitlyn N. LewisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lin, Tzu Hua D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mason, Matthew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McCloskey, DanUNSPECIFIEDorcid.org/0000-0003-3596-8014UNSPECIFIED
McMahon, MaryUNSPECIFIEDorcid.org/0000-0001-5548-2949UNSPECIFIED
Miura, KyokoUNSPECIFIEDorcid.org/0000-0003-2208-149XUNSPECIFIED
Mogi, KazutakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Narayan, VikramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Connor, Timothy P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okanoya, KazuoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Riain, M. JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Place, Ned J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Podshivalova, KatieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pamenter, Matthew E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pyott, Sonja J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reznick, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruby, J. GrahamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmon, Adam B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos-Sacchi, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarko, Diana K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seluanov, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shepard, AlyssaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, MeganUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storey, Kenneth B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tian, XiaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vice, Emily N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viltard, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Watarai, AkiyukiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wywial, EwaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yamakawa, MasanoriUNSPECIFIEDorcid.org/0000-0002-4120-8874UNSPECIFIED
Zemlemerova, Elena D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zions, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Ewan St JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607977
DOI: 10.1111/brv.12791
Journal or Publication Title: Biol. Rev.
Volume: 97
Number: 1
Page Range: S. 115 - 141
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1469-185X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONGEST-LIVING RODENT; BROWN ADIPOSE-TISSUE; AGE-RELATED-CHANGES; HETEROCEPHALUS-GLABER; CRYPTOMYS-DAMARENSIS; VOCAL COMMUNICATION; BURROW ARCHITECTURE; SOMATOSENSORY ORGANIZATION; ECOPHYSIOLOGICAL RESPONSES; PAIN INSENSITIVITYMultiple languages
BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60797

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