Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J. B., Boada, Merce, Parnetti, Lucilla ORCID: 0000-0001-5722-3967, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleo, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius ORCID: 0000-0002-0068-0312, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chetelat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning ORCID: 0000-0003-2346-0598, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort-Merino, Adria, Binette, Alexa Pichet, Poirier, Judes, Rosa-Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel ORCID: 0000-0002-3819-3245, Fortea, Juan ORCID: 0000-0002-1340-638X, Sanchez-Saudinos, M. Belen, Ebenau, Jarith, Pocnet, Cornelia, Eckerstrom, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne ORCID: 0000-0001-6863-6679, Wallin, Asa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald ORCID: 0000-0003-0894-8982, Spiru, Luiza, Tijms, Betty, Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank and Visser, Pieter Jelle ORCID: 0000-0001-8008-9727 . Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Janssen, OlinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, Willemijn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vos, Stephanie J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boada, MerceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parnetti, LucillaUNSPECIFIEDorcid.org/0000-0001-5722-3967UNSPECIFIED
Gabryelewicz, TomaszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fladby, TormodUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molinuevo, Jose LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villeneuve, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hort, JakubUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Epelbaum, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lleo, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelborghs, SebastiaanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Flier, Wiesje M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landau, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popp, JuliusUNSPECIFIEDorcid.org/0000-0002-0068-0312UNSPECIFIED
Wallin, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rikkert, Marcel OldeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snyder, Peter J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rowe, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chetelat, GaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruiz, AgustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marquie, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chipi, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boecker, HenningUNSPECIFIEDorcid.org/0000-0003-2346-0598UNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarholm, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rami, LorenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tort-Merino, AdriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Binette, Alexa PichetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poirier, JudesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosa-Neto, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cerman, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teichmann, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alcolea, DanielUNSPECIFIEDorcid.org/0000-0002-3819-3245UNSPECIFIED
Fortea, JuanUNSPECIFIEDorcid.org/0000-0002-1340-638XUNSPECIFIED
Sanchez-Saudinos, M. BelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ebenau, JarithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pocnet, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eckerstrom, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thompson, LouisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villemagne, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buckley, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burnham, SamanthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delarue, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freund-Levi, YvonneUNSPECIFIEDorcid.org/0000-0001-6863-6679UNSPECIFIED
Wallin, Asa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramakers, InezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsolaki, MagdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soininen, HilkkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDorcid.org/0000-0003-0894-8982UNSPECIFIED
Spiru, LuizaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tijms, BettyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ossenkoppele, RikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhey, Frans R. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser, Pieter JelleUNSPECIFIEDorcid.org/0000-0001-8008-9727UNSPECIFIED
URN: urn:nbn:de:hbz:38-607983
DOI: 10.1002/alz.12512
Journal or Publication Title: Alzheimers. Dement.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PRECLINICAL ALZHEIMERS-DISEASE; MEMORY COMPLAINTS; OLDER-ADULTS; DEMENTIA; POPULATION; RISK; COMMUNITY; PREVALENCE; DEPOSITION; SYMPTOMSMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60798

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