Seppala, Toni T., Dominguez-Valentin, Mev, Crosbie, Emma J., Engel, Christoph ORCID: 0000-0002-7247-282X, Aretz, Stefan ORCID: 0000-0002-5228-1890, Macrae, Finlay, Winship, Ingrid, Capella, Gabriel, Thomas, Huw, Hovig, Eivind ORCID: 0000-0002-9103-1077, Nielsen, Maartje, Sijmons, Rolf H., Bertario, Lucio, Bonanni, Bernardo, Tibiletti, Maria G., Cavestro, Giulia M., Mints, Miriam, Gluck, Nathan, Katz, Lior, Heinimann, Karl, Vaccaro, Carlos A., Green, Kate, Lalloo, Fiona, Hill, James, Schmiegel, Wolff, Vangala, Deepak ORCID: 0000-0002-4175-5683, Perne, Claudia, Strauss, Hans-Georg, Tecklenburg, Johanna, Holinski-Feder, Elke, Steinke-Lange, Verena, Mecklin, Jukka-Pekka, Plazzer, John-Paul, Pineda, Marta, Navarro, Matilde, Vida, Joan B., Kariv, Revital, Rosner, Guy, Pinero, Tamara A., Pavicic, Walter, Kalfayan, Pablo, Ten Broeke, Sanne W., Jenkins, Mark A., Sunde, Lone ORCID: 0000-0002-8479-165X, Bernstein, Inge, Burn, John, Greenblatt, Marc, Cappel, Wouter H. de Vos Tot Nederveen, Della Valle, Adriana, Lopez-Koestner, Francisco, Alvarez, Karin, Buettner, Reinhard, Goergens, Heike, Morak, Monika, Holzapfel, Stefanie, Hueneburg, Robert, Doeberitz, Magnus von Knebel, Loeffler, Markus, Redler, Silke, Weitz, Jurgen, Pylvaenaeinen, Kirsi, Renkonen-Sinisalo, Laura, Lepisto, Anna, Hopper, John L., Win, Aung K., Lindor, Noralane M., Gallinger, Steven, Marchand, Loic Le, Newcomb, Polly A., Figueiredo, Jane C., Thibodeau, Stephen N., Therkildsen, Christina, Wadt, Karin A. W., Mourits, Marian J. E., Ketabi, Zohreh, Denton, Oliver G., Rodland, Einar A., Vasen, Hans, Neffa, Florencia, Esperon, Patricia, Tjandra, Douglas, Moeslein, Gabriela, Rokkones, Erik, Sampson, Julian R., Evans, D. G. and Moller, Pal (2021). Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Eur. J. Cancer, 148. S. 124 - 134. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Purpose: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. Results: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. Conclusion: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene-and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syn-drome to improve outcomes. (C) 2021 The Author(s). Published by Elsevier Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seppala, Toni T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominguez-Valentin, MevUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crosbie, Emma J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Aretz, StefanUNSPECIFIEDorcid.org/0000-0002-5228-1890UNSPECIFIED
Macrae, FinlayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winship, IngridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capella, GabrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, HuwUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hovig, EivindUNSPECIFIEDorcid.org/0000-0002-9103-1077UNSPECIFIED
Nielsen, MaartjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sijmons, Rolf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertario, LucioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonanni, BernardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tibiletti, Maria G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavestro, Giulia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mints, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gluck, NathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katz, LiorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinimann, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaccaro, Carlos A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Green, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lalloo, FionaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmiegel, WolffUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vangala, DeepakUNSPECIFIEDorcid.org/0000-0002-4175-5683UNSPECIFIED
Perne, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, Hans-GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tecklenburg, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holinski-Feder, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinke-Lange, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mecklin, Jukka-PekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plazzer, John-PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pineda, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navarro, MatildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vida, Joan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kariv, RevitalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosner, GuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinero, Tamara A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavicic, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalfayan, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ten Broeke, Sanne W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkins, Mark A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sunde, LoneUNSPECIFIEDorcid.org/0000-0002-8479-165XUNSPECIFIED
Bernstein, IngeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burn, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenblatt, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cappel, Wouter H. de Vos Tot NederveenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Della Valle, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Koestner, FranciscoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goergens, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morak, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holzapfel, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hueneburg, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doeberitz, Magnus von KnebelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loeffler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Redler, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weitz, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pylvaenaeinen, KirsiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renkonen-Sinisalo, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lepisto, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Win, Aung K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindor, Noralane M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallinger, StevenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchand, Loic LeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Newcomb, Polly A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueiredo, Jane C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thibodeau, Stephen N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Therkildsen, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wadt, Karin A. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourits, Marian J. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ketabi, ZohrehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denton, Oliver G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodland, Einar A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasen, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neffa, FlorenciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esperon, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tjandra, DouglasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeslein, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rokkones, ErikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampson, Julian R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moller, PalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608122
DOI: 10.1016/j.ejca.2021.02.022
Journal or Publication Title: Eur. J. Cancer
Volume: 148
Page Range: S. 124 - 134
Date: 2021
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1879-0852
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SURGERYMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60812

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