Velthorst, Eva ORCID: 0000-0002-9240-2909, Mollon, Josephine, Murray, Robin M., de Haan, Lieuwe, Germeys, Inez Myin, Glahn, David C., Arango, Celso ORCID: 0000-0003-3382-4754, van der Ven, Els ORCID: 0000-0001-5103-7186, Di Forti, Marta, Bernardo, Miguel, Guloksuz, Sinan ORCID: 0000-0002-6626-1874, Delespaul, Philippe ORCID: 0000-0001-7420-0898, Mezquida, Gisela ORCID: 0000-0002-6080-2203, Amoretti, Silvia ORCID: 0000-0001-6017-2734, Bobes, Julio ORCID: 0000-0003-2187-4033, Saiz, Pilar A. ORCID: 0000-0002-5705-4523, Garcia-Portilla, Maria Paz, Santos, Jose Luis, Jimenez-Lopez, Estela, Sanjuan, Julio, Aguilar, Eduardo J., Arrojo, Manuel, Carracedo, Angel ORCID: 0000-0003-1085-8986, Lopez, Gonzalo, Gonzalez-Penas, Javier, Parellada, Mara ORCID: 0000-0001-7977-3601, Atbasoglu, Cem, Saka, Meram Can, Ucok, Alp, Alptekin, Koksal, Akdede, Berna, Binbay, Tolga, Altinyazar, Vesile, Ulas, Halis, Yalincetin, Berna, Gumus-Akay, Guvem, Beyaz, Burcin Cihan, Soygur, Haldun, Cankurtaran, Eylem Sahin, Kaymak, Semra Ulusoy, Maric, Nadja P., Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Del-Ben, Cristina Marta, Ferraro, Laura, Gayer-Anderson, Charlotte ORCID: 0000-0003-1636-889X, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B. ORCID: 0000-0003-3401-0824, La Cascia, Caterina ORCID: 0000-0002-2078-0214, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Morgan, Craig ORCID: 0000-0002-1386-2369, Quattrone, Diego, Menchetti, Marco, Selten, Jean-Paul, Szoke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, McGuire, Philip ORCID: 0000-0003-4381-0532, Valmaggia, Lucia ORCID: 0000-0001-6099-8464, Kempton, Matthew J., van der Gaag, Mark ORCID: 0000-0002-3525-6415, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, Nelson, Barnaby ORCID: 0000-0002-6263-2332, McGorry, Patrick ORCID: 0000-0002-3789-6168, Pantelis, Chris, Krebs, Marie-Odile ORCID: 0000-0002-4715-9890, Ruhrmann, Stephan, Sachs, Gabriele ORCID: 0000-0002-8359-9877, Rutten, Bart P. F., van Os, Jim, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, van Beveren, Nico J., Luykx, Jurjen J., Cahn, Wiepke, Simons, Claudia J. P., Kahn, Rene S., Schirmbeck, Frederike ORCID: 0000-0003-1700-0958, van Winkel, Ruud and Reichenberg, Abraham (2021). Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings. Mol. Psychiatr., 26 (8). S. 4529 - 4544. LONDON: SPRINGERNATURE. ISSN 1476-5578

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Abstract

Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Velthorst, EvaUNSPECIFIEDorcid.org/0000-0002-9240-2909UNSPECIFIED
Mollon, JosephineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, Robin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Haan, LieuweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Germeys, Inez MyinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glahn, David C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arango, CelsoUNSPECIFIEDorcid.org/0000-0003-3382-4754UNSPECIFIED
van der Ven, ElsUNSPECIFIEDorcid.org/0000-0001-5103-7186UNSPECIFIED
Di Forti, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernardo, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guloksuz, SinanUNSPECIFIEDorcid.org/0000-0002-6626-1874UNSPECIFIED
Delespaul, PhilippeUNSPECIFIEDorcid.org/0000-0001-7420-0898UNSPECIFIED
Mezquida, GiselaUNSPECIFIEDorcid.org/0000-0002-6080-2203UNSPECIFIED
Amoretti, SilviaUNSPECIFIEDorcid.org/0000-0001-6017-2734UNSPECIFIED
Bobes, JulioUNSPECIFIEDorcid.org/0000-0003-2187-4033UNSPECIFIED
Saiz, Pilar A.UNSPECIFIEDorcid.org/0000-0002-5705-4523UNSPECIFIED
Garcia-Portilla, Maria PazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos, Jose LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimenez-Lopez, EstelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanjuan, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aguilar, Eduardo J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arrojo, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carracedo, AngelUNSPECIFIEDorcid.org/0000-0003-1085-8986UNSPECIFIED
Lopez, GonzaloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Penas, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parellada, MaraUNSPECIFIEDorcid.org/0000-0001-7977-3601UNSPECIFIED
Atbasoglu, CemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saka, Meram CanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ucok, AlpUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alptekin, KoksalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akdede, BernaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Binbay, TolgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altinyazar, VesileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ulas, HalisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yalincetin, BernaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gumus-Akay, GuvemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyaz, Burcin CihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soygur, HaldunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cankurtaran, Eylem SahinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaymak, Semra UlusoyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maric, Nadja P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mihaljevic, Marina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrovic, Sanja AndricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mirjanic, TijanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del-Ben, Cristina MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferraro, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gayer-Anderson, CharlotteUNSPECIFIEDorcid.org/0000-0003-1636-889XUNSPECIFIED
Jones, Peter B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jongsma, Hannah E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirkbride, James B.UNSPECIFIEDorcid.org/0000-0003-3401-0824UNSPECIFIED
La Cascia, CaterinaUNSPECIFIEDorcid.org/0000-0002-2078-0214UNSPECIFIED
Lasalvia, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tosato, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Llorca, Pierre-MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menezes, Paulo RossiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morgan, CraigUNSPECIFIEDorcid.org/0000-0002-1386-2369UNSPECIFIED
Quattrone, DiegoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menchetti, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Selten, Jean-PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szoke, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tarricone, IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tortelli, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuire, PhilipUNSPECIFIEDorcid.org/0000-0003-4381-0532UNSPECIFIED
Valmaggia, LuciaUNSPECIFIEDorcid.org/0000-0001-6099-8464UNSPECIFIED
Kempton, Matthew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Gaag, MarkUNSPECIFIEDorcid.org/0000-0002-3525-6415UNSPECIFIED
Riecher-Rossler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressan, Rodrigo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrantes-Vidal, NeusUNSPECIFIEDorcid.org/0000-0002-8671-1238UNSPECIFIED
Nelson, BarnabyUNSPECIFIEDorcid.org/0000-0002-6263-2332UNSPECIFIED
McGorry, PatrickUNSPECIFIEDorcid.org/0000-0002-3789-6168UNSPECIFIED
Pantelis, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krebs, Marie-OdileUNSPECIFIEDorcid.org/0000-0002-4715-9890UNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachs, GabrieleUNSPECIFIEDorcid.org/0000-0002-8359-9877UNSPECIFIED
Rutten, Bart P. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Os, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alizadeh, Behrooz Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Amelsvoort, ThereseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartels-Velthuis, Agna A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruggeman, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Beveren, Nico J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luykx, Jurjen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cahn, WiepkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simons, Claudia J. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahn, Rene S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schirmbeck, FrederikeUNSPECIFIEDorcid.org/0000-0003-1700-0958UNSPECIFIED
van Winkel, RuudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichenberg, AbrahamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608217
DOI: 10.1038/s41380-020-00969-z
Journal or Publication Title: Mol. Psychiatr.
Volume: 26
Number: 8
Page Range: S. 4529 - 4544
Date: 2021
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5578
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SCHIZOPHRENIA-PATIENTS; GENETIC RISK; RELIABILITY; VALIDITY; DEFICITS; IMPAIRMENT; CHILDHOOD; EPISODE; DECLINE; ABILITYMultiple languages
Biochemistry & Molecular Biology; Neurosciences; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60821

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