Boltze, Johannes, Aronowski, Jaroslaw A., Badaut, Jerome, Buckwalter, Marion S., Caleo, Mateo, Chopp, Michael, Dave, Kunjan R., Didwischus, Nadine, Dijkhuizen, Rick M., Doeppner, Thorsten R., Dreier, Jens P., Fouad, Karim, Gelderblom, Mathias, Gertz, Karen ORCID: 0000-0002-1203-641X, Golubczyk, Dominika ORCID: 0000-0001-5692-6329, Gregson, Barbara A., Hamel, Edith, Hanley, Daniel F., Haertig, Wolfgang, Hummel, Friedhelm C., Ikhsan, Maulana, Janowski, Miroslaw ORCID: 0000-0001-5261-7975, Jolkkonen, Jukka, Karuppagounder, Saravanan S., Keep, Richard F., Koerte, Inga K., Kokaia, Zaal, Li, Peiying, Liu, Fudong, Lizasoain, Ignacio, Ludewig, Peter, Metz, Gerlinde A. S., Montagne, Axel, Obenaus, Andre, Palumbo, Alex ORCID: 0000-0002-1631-785X, Pearl, Monica, Perez-Pinzon, Miguel, Planas, Anna M., Plesnila, Nikolaus, Raval, Ami P., Rueger, Maria A., Sansing, Lauren H., Sohrabji, Farida, Stagg, Charlotte J., Stetler, R. Anne, Stowe, Ann M., Sun, Dandan, Taguchi, Akihiko, Tanter, Mickael, Vay, Sabine U., Vemuganti, Raghu, Vivien, Denis, Walczak, Piotr, Wang, Jian ORCID: 0000-0003-2291-640X, Xiong, Ye and Zille, Marietta ORCID: 0000-0002-0609-8956 (2021). New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases. Front. Aging Neurosci., 13. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Boltze, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aronowski, Jaroslaw A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Badaut, JeromeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buckwalter, Marion S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caleo, MateoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chopp, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dave, Kunjan R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Didwischus, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dijkhuizen, Rick M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doeppner, Thorsten R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreier, Jens P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fouad, KarimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gelderblom, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gertz, KarenUNSPECIFIEDorcid.org/0000-0002-1203-641XUNSPECIFIED
Golubczyk, DominikaUNSPECIFIEDorcid.org/0000-0001-5692-6329UNSPECIFIED
Gregson, Barbara A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamel, EdithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanley, Daniel F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haertig, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hummel, Friedhelm C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ikhsan, MaulanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowski, MiroslawUNSPECIFIEDorcid.org/0000-0001-5261-7975UNSPECIFIED
Jolkkonen, JukkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karuppagounder, Saravanan S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keep, Richard F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koerte, Inga K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kokaia, ZaalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, PeiyingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, FudongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lizasoain, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ludewig, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metz, Gerlinde A. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montagne, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obenaus, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palumbo, AlexUNSPECIFIEDorcid.org/0000-0002-1631-785XUNSPECIFIED
Pearl, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Pinzon, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Planas, Anna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plesnila, NikolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raval, Ami P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueger, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sansing, Lauren H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohrabji, FaridaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stagg, Charlotte J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stetler, R. AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stowe, Ann M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, DandanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taguchi, AkihikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tanter, MickaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vay, Sabine U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vemuganti, RaghuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vivien, DenisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walczak, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, JianUNSPECIFIEDorcid.org/0000-0003-2291-640XUNSPECIFIED
Xiong, YeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zille, MariettaUNSPECIFIEDorcid.org/0000-0002-0609-8956UNSPECIFIED
URN: urn:nbn:de:hbz:38-608233
DOI: 10.3389/fnagi.2021.623751
Journal or Publication Title: Front. Aging Neurosci.
Volume: 13
Date: 2021
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1663-4365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Geriatrics & Gerontology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60823

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