Zaborowski, Alexandra M., Abdile, Ahmed, Adamina, Michel, Aigner, Felix ORCID: 0000-0001-8931-736X, d'Allens, Laura, Allmer, Caterina, Alvarez, Andrea, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon ORCID: 0000-0001-8412-7241, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Bebington, Brendan, Beggs, Andrew ORCID: 0000-0003-0784-2967, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Boutall, Adam ORCID: 0000-0002-6413-5890, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D., Buchwald, Pamela, Burger, Jacobus W. A., Burlov, Nikita ORCID: 0000-0003-3407-4406, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David ORCID: 0000-0002-2065-3012, Climent, Marta, Cologne, Kyle G., Contreras, Tomas, Croner, Roland, Daniels, Ian R., Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D'Hoore, Andre, Drozdov, Evgeniy ORCID: 0000-0003-4157-9744, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina ORCID: 0000-0001-7583-2109, Faiz, Omar, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Figueiredo, Nuno ORCID: 0000-0002-5582-0933, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Gong, Jianping, Goran, Barisic, Greenwood, Emma, Guren, Marianne G., Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hoffmeister, Michael ORCID: 0000-0002-8307-3197, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah Dorna, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A., Keller, Deborah S., Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Peter, Koh, Cherry, Kok, Neils, Knight, Katrina A., Knol, Joep, Kontovounisios, Christos, Korner, Hartwig, Krivokapic, Zoran, Kronberger, Irmgard, Kroon, Hidde Maarten, Kryzauskas, Marius, Kural, Said ORCID: 0000-0001-5555-8421, Kusters, Miranda, Lakkis, Zaher ORCID: 0000-0002-2608-5896, Lankov, Timur, Larson, Dave, Lazar, Gyorgy, Lee, Kai-Yin, Lee, Suk Hwan, Lefevre, Jeremie H., Lepisto, Anna, Lieu, Christopher, Loi, Lynette, Lynch, Craig, Maillou-Martinaud, Helene, Maroli, Annalisa, Martin, Sean, Martling, Anna, Matzel, Klaus E., Mayol, Julio ORCID: 0000-0003-2411-6668, McDermott, Frank, Meurette, Guillaume, Millan, Monica, Mitteregger, Martin, Moiseenko, Andrei, Monson, John R. T., Morarasu, Stefan, Moritani, Konosuke, Moslein, Gabriela, Munini, Martino, Nahas, Caio, Nahas, Sergio, Negoi, Ionut, Novikova, Anastasia, Ocares, Misael, Okabayashi, Koji, Olkina, Alexandra, Onate-Ocana, Luis, Otero, Jaime, Ozen, Cihan, Pace, Ugo, Juliao, Guilherme Pagin Sao, Panaiotti, Lidiia, Panis, Yves, Papamichael, Demetris, Park, Jason, Patel, Swati, Uriburu, Juan Carlos Patron, Pera, Miguel, Perez, Rodrigo O., Petrov, Alexei, Pfeffer, Frank, Phang, P. Terry, Poskus, Tomas, Pringle, Heather, Proud, David, Raguz, Ivana, Rama, Nuno, Rasheed, Shahnawaz, Raval, Manoj J., Rega, Daniela, Reissfelder, Christoph, Meneses, Juan Carlos Reyes, Ris, Frederic ORCID: 0000-0001-7421-6101, Riss, Stefan, Rodriguez-Zentner, Homero, Roxburgh, Campbell S., Saklani, Avanish ORCID: 0000-0003-4498-7612, Salido, Andrea Jimenez, Sammour, Tarik, Saraste, Deborah, Schneider, Martin, Seishima, Ryo, Sekulic, Aleksandar, Seppala, Toni, Sheahan, Kieran, Shine, Rebecca, Shlomina, Alexandra, Sica, Guiseppe S., Singnomklao, Tongplaew, Siragusa, Leandro, Smart, Neil, Solis, Alejandro, Spinelli, Antonino, Staiger, Roxane D., Stamos, Michael J., Steele, Scott, Sunderland, Michael, Tan, Ker-Kan, Tanis, Pieter J., Tekkis, Paris, Teklay, Biniam, Tengku, Sabrina, Jimenez-Toscano, Marta, Tsarkov, Petr, Turina, Matthias, Ulrich, Alexis, Vailati, Bruna B., van Harten, Meike, Verhoef, Cornelis, Warrier, Satish, Wexner, Steve, de Wilt, Hans, Weinberg, Benjamin A., Wells, Cameron, Wolthuis, Albert, Xynos, Evangelos, You, Nancy, Zakharenko, Alexander, Zeballos, Justino and Winter, Des C. (2021). Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review. JAMA Surg., 156 (9). S. 865 - 875. CHICAGO: AMER MEDICAL ASSOC. ISSN 2168-6262

Full text not available from this repository.

Abstract

IMPORTANCE The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. OBSERVATIONS Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include aWesternized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. CONCLUSIONS AND RELEVANCE The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zaborowski, Alexandra M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abdile, AhmedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adamina, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aigner, FelixUNSPECIFIEDorcid.org/0000-0001-8931-736XUNSPECIFIED
d'Allens, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allmer, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anula, RocioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andric, MihailoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atallah, SamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bach, SimonUNSPECIFIEDorcid.org/0000-0001-8412-7241UNSPECIFIED
Bala, MikloshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barussaud, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bausys, AugustinasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bebington, BrendanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beggs, AndrewUNSPECIFIEDorcid.org/0000-0003-0784-2967UNSPECIFIED
Bellolio, FelipeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bennett, Melissa-RoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berdinskikh, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bevan, VickiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biondo, SebastianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bislenghi, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bludau, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boutall, AdamUNSPECIFIEDorcid.org/0000-0002-6413-5890UNSPECIFIED
Brouwer, NellekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brown, CarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchanan, Daniel D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchwald, PamelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burger, Jacobus W. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burlov, NikitaUNSPECIFIEDorcid.org/0000-0003-3407-4406UNSPECIFIED
Campanelli, MichelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capdepont, MaylisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carvello, MicheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chew, Hwee-HoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Christoforidis, DimitriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clark, DavidUNSPECIFIEDorcid.org/0000-0002-2065-3012UNSPECIFIED
Climent, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cologne, Kyle G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Croner, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daniels, Ian R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dapri, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davies, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delrio, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denost, QuentinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deutsch, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dias, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Hoore, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drozdov, EvgeniyUNSPECIFIEDorcid.org/0000-0003-4157-9744UNSPECIFIED
Duek, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunlop, MalcolmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dziki, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edmundson, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Efetov, SergeyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Hussuna, AlaaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elliot, BrodieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emile, SamehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espin, EloyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, MartynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faes, SerainaUNSPECIFIEDorcid.org/0000-0001-7583-2109UNSPECIFIED
Faiz, OmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleming, FergalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Fowler, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Figueiredo, NunoUNSPECIFIEDorcid.org/0000-0002-5582-0933UNSPECIFIED
Forgan, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frizelle, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gadaev, ShamilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gellona, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glyn, TamaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gong, JianpingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goran, BarisicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenwood, EmmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guren, Marianne G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guillon, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutlic, IdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahnloser, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HeatherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanly, AnnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasegawa, HirotoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iversen, Lene HjerrildUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoch, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmeister, MichaelUNSPECIFIEDorcid.org/0000-0002-8307-3197UNSPECIFIED
Hompes, RoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hurtado, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iaquinandi, FabianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Imbrasaite, UgneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Islam, RumanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jafari, Mehrenah DornaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanemitsu, YukihideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karachun, AlekseiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karimuddin, Ahmer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller, Deborah S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kelly, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kennelly, RoryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khrykov, GlebUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kocian, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koh, CherryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kok, NeilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knight, Katrina A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knol, JoepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kontovounisios, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korner, HartwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krivokapic, ZoranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kronberger, IrmgardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroon, Hidde MaartenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kryzauskas, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Kusters, MirandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lakkis, ZaherUNSPECIFIEDorcid.org/0000-0002-2608-5896UNSPECIFIED
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Lee, Suk HwanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lefevre, Jeremie H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Loi, LynetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lynch, CraigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maillou-Martinaud, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maroli, AnnalisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, SeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martling, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matzel, Klaus E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayol, JulioUNSPECIFIEDorcid.org/0000-0003-2411-6668UNSPECIFIED
McDermott, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meurette, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Millan, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mitteregger, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moiseenko, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monson, John R. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morarasu, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moritani, KonosukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moslein, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munini, MartinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nahas, CaioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nahas, SergioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Negoi, IonutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novikova, AnastasiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ocares, MisaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okabayashi, KojiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olkina, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Ozen, CihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pace, UgoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juliao, Guilherme Pagin SaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panaiotti, LidiiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Tan, Ker-KanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tanis, Pieter J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tekkis, ParisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teklay, BiniamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tengku, SabrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimenez-Toscano, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsarkov, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turina, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ulrich, AlexisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vailati, Bruna B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Harten, MeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhoef, CornelisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warrier, SatishUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wexner, SteveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Wilt, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinberg, Benjamin A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wells, CameronUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolthuis, AlbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xynos, EvangelosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
You, NancyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zakharenko, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeballos, JustinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winter, Des C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608486
DOI: 10.1001/jamasurg.2021.2380
Journal or Publication Title: JAMA Surg.
Volume: 156
Number: 9
Page Range: S. 865 - 875
Date: 2021
Publisher: AMER MEDICAL ASSOC
Place of Publication: CHICAGO
ISSN: 2168-6262
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LYNCH SYNDROME; INCREASING INCIDENCE; GUT MICROBIOTA; RECTAL-CANCER; UNITED-STATES; YOUNG-ADULTS; RISK; AGE; ADENOCARCINOMA; FEATURESMultiple languages
SurgeryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60848

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