Universität zu Köln

Strelow, Joshua N., Dembek, Till A., Baldermann, Juan C., Andrade, Pablo ORCID: 0000-0002-2596-7301, Jergas, Hannah, Visser-Vandewalle, Veerle and Barbe, Michael T. (2022). Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson's Disease. Brain Sci., 12 (12). BASEL: MDPI. ISSN 2076-3425

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Abstract

Intra- and perioperatively recorded local field potential (LFP) activity of the nucleus subthalamicus (STN) has been suggested to guide contact selection in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD). Despite the invention of sensing capacities in chronically implanted devices, a comprehensible algorithm that enables contact selection using such recordings is still lacking. We evaluated a fully automated algorithm that uses the weighted average of bipolar recordings to determine effective monopolar contacts based on elevated activity in the beta band. LFPs from 14 hemispheres in seven PD patients with newly implanted directional DBS leads of the STN were recorded. First, the algorithm determined the stimulation level with the highest beta activity. Based on the prior determined level, the directional contact with the highest beta activity was chosen in the second step. The mean clinical efficacy of the contacts chosen using the algorithm did not statistically differ from the mean clinical efficacy of standard contact selection as performed in clinical routine. All recording sites were projected into MNI standard space to investigate the feasibility of the algorithm with respect to the anatomical boundaries of the STN. We conclude that the proposed algorithm is a first step towards LFP-based contact selection in STN-DBS for PD using chronically implanted devices.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Strelow, Joshua N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, Juan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrade, Pablo UNSPECIFIED orcid.org/0000-0002-2596-7301 UNSPECIFIED Jergas, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-657680
DOI:	10.3390/brainsci12121726
Journal or Publication Title:	Brain Sci.
Volume:	12
Number:	12
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN SUBTHALAMIC NUCLEUS; BASAL GANGLIA; BETA OSCILLATIONS; MOTOR; RECORDINGS; DOPAMINE; ALGORITHMS; PARALLEL; TREMOR Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65768