Universität zu Köln

Erven, Ilka ORCID: 0000-0002-1095-6861, Abraham, Elena, Hermanns, Thomas ORCID: 0000-0001-5350-7479, Baumann, Ulrich and Hofmann, Kay (2022). A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins. Nat. Commun., 13 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

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Abstract

Distinct families of eukaryotic deubiquitinases (DUBs) are regulators of ubiquitin signaling. Here, we report on the presence of an additional DUB class broadly distributed in eukaryotes and several bacteria. The only described members of this family are the large tegument proteins of herpesviruses, which are attached to the outside of the viral capsid. By using a bioinformatics screen, we have identified distant homologs of this VTD (Viral tegument-like DUB) family in vertebrate transposons, fungi, insects, nematodes, cnidaria, protists and bacteria. While some VTD activities resemble viral tegument DUBs in that they favor K48-linked ubiquitin chains, other members are highly specific for K6- or K63-linked ubiquitin chains. The crystal structures of K48- and K6-specific members reveal considerable differences in ubiquitin recognition. The VTD family likely evolved from non-DUB proteases and spread through transposons, many of which became `domesticated', giving rise to the Drosophila male sterile (3)76Ca gene and several nematode genes with male-specific expression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erven, Ilka UNSPECIFIED orcid.org/0000-0002-1095-6861 UNSPECIFIED Abraham, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermanns, Thomas UNSPECIFIED orcid.org/0000-0001-5350-7479 UNSPECIFIED Baumann, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofmann, Kay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-658262
DOI:	10.1038/s41467-022-35244-y
Journal or Publication Title:	Nat. Commun.
Volume:	13
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYSTEINE PROTEASES; UBIQUITIN CHAINS; MECHANISM; REVEALS; DOMAIN; RING; SOFTWARE; EFFECTOR; INSIGHTS; VERSION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65826