Universität zu Köln

Stracke, Claudia, Lemmen, Clarissa ORCID: 0000-0001-9205-6551, Rhiem, Kerstin, Schmutzler, Rita, Kautz-Freimuth, Sibylle and Stock, Stephanie (2022). You Always Have It in the Back of Your Mind-Feelings, Coping, and Support Needs of Women with Pathogenic Variants in Moderate-Risk Genes for Hereditary Breast Cancer Attending Genetic Counseling in Germany: A Qualitative Interview Study. Int. J. Environ. Res. Public Health, 19 (6). BASEL: MDPI. ISSN 1660-4601

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Abstract

Hereditary breast cancer accounts for approximately 30% of newly diagnosed breast cancer (BC) cases. Pathogenic variants in moderate-risk BC genes (MBCG) differ from those in high-risk genes in terms of associated cancer risks, affected organs, and available preventive options. Little is known about how MBCG pathogenic variant carriers who have attended post-test genetic counseling perceive their situation, how they cope with their situation, and which support needs they might have. Problem-centered, guided, individual interviews were conducted with twelve women carrying pathogenic variants in MBCG. The interview analysis was based on Mayring's qualitative content analysis. The women were between 29 and 59 years old and carried pathogenic variants in the risk genes CHEK2 (n = 8), ATM (n = 1), or PALB2 (n = 3). Women reported a wide range of feelings, both positive (relief, calmness) and negative (overwhelm, fear, grief, guilt). All women applied strategies of emotion-focused coping to deal with this lifelong situation. Appraisal and evaluation of the affected mother's coping might influence the patient's own behavior and coping style. These results could be used during and after post-test genetic counseling to provide more needs-oriented counseling, and to help women in adjusting to and coping with being a pathogenic variant carrier.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stracke, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemmen, Clarissa UNSPECIFIED orcid.org/0000-0001-9205-6551 UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Kautz-Freimuth, Sibylle UNSPECIFIED UNSPECIFIED UNSPECIFIED Stock, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-659203
DOI:	10.3390/ijerph19063525
Journal or Publication Title:	Int. J. Environ. Res. Public Health
Volume:	19
Number:	6
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-4601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GERMLINE MUTATIONS; OVARIAN-CANCER; SUSCEPTIBILITY; BRCA1; PENETRANCE; DISCLOSURE; MANAGEMENT; KNOWLEDGE; FAMILIES; MOTHER Multiple languages Environmental Sciences; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65920