Universität zu Köln

Schoemig, Charlotte, Oberholz, Laura, Fink, Gregor, Voggel, Jenny, Wohlfarth, Maria, Doetsch, Joerg, Nuesken, Kai-Dietrich and Nuesken, Eva (2022). Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction. Nutrients, 14 (3). BASEL: MDPI. ISSN 2072-6643

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Abstract

Fetal growth restriction (FGR) has been linked to long-term neurocognitive impairment, especially in males. To determine possible underlying mechanisms, we examined hippocampal cellular composition and mTOR signaling of male rat FGR offspring during main brain growth and development (postnatal days (PND) 1 and 12). FGR was either induced by a low-protein diet throughout pregnancy, experimental placental insufficiency by bilateral uterine vessel ligation or intrauterine stress by sham operation. Offspring after unimpaired gestation served as common controls. Low-protein diet led to a reduced cell density in the molecular dentate gyrus subregion, while intrauterine surgical stress was associated with increased cell density in the cellular CA2 subregion. Experimental placental insufficiency caused increased mTOR activation on PND 1, whereas intrauterine stress led to mTOR activation on PND 1 and 12. To determine long-term effects, we additionally examined mTOR signaling and Tau phosphorylation, which is altered in neurodegenerative diseases, on PND 180, but did not find any changes among the experimental groups. Our findings suggest that hippocampal cellular proliferation and mTOR signaling are dysregulated in different ways depending on the cause of FGR. While a low-protein diet induced a decreased cell density, prenatal surgical stress caused hyperproliferation, possibly via increased mTOR signaling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schoemig, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberholz, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Voggel, Jenny UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlfarth, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Kai-Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-659227
DOI:	10.3390/nu14030451
Journal or Publication Title:	Nutrients
Volume:	14
Number:	3
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOR-GESTATIONAL-AGE; PERINATAL PROTEIN-MALNUTRITION; UTEROPLACENTAL INSUFFICIENCY; CHROMATIN-STRUCTURE; MAMMALIAN TARGET; PRENATAL STRESS; MEMORY FUNCTION; BIRTH-WEIGHT; FOLLOW-UP; CHILDREN Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65922