Universität zu Köln

Schoeneberger, Verena, Menghesha, Leonie ORCID: 0000-0003-0936-2414, Gerlach, Stefanie, Gietzelt, Caroline ORCID: 0000-0002-9145-7385, Eberhardt, Somaie, Cursiefen, Claus and Schaub, Friederike ORCID: 0000-0003-2648-1626 (2023). Lens status and degree of lens opacity influence laser flare photometry (objective tyndallometry). Eur. J. Ophthalmol., 33 (2). S. 943 - 949. LONDON: SAGE PUBLICATIONS LTD. ISSN 1724-6016

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Abstract

Purpose Objective tyndallometry using laser flare photometry can be utilized e.g., in management of uveitis. Previous studies showed a significant difference in flare values between pseudophakic and phakic eyes. We investigate a potential association between the degree of lens opacification and flare value in a large cohort phakic eyes. Methods Retrospective, non-interventional single center study. Laser flare values of 460 healthy fellow eyes from two large cohorts (primary rhegmatogenous retinal detachment (RRD), macular holes (MH)) were correlated with lens status, degree of lens opacity, and age. Results Out of 460 patients (mean age 64.6 +/- 11.2, 57% male) 30.4% were pseudophakic (70.2 +/- 10.9) and 69.6% phakic, of which 47.8% showed a clear lens (57.3 +/- 9.1), 43.2% an mild cataract (65.2 +/- 9.0) and 9.0% a moderate cataract (73.5 +/- 9.0). In pseudophakia, flare (8.14 +/- 4.6 pc/ms) was significantly higher compared to phakia (6.4 +/- 3.9 pc/ms; p < 0.001). In phakic eyes, flare values increased significantly with increasing lens opacity (clear lens 5.3 +/- 2.8 pc/ms; mild cataract 7.0 +/- 4.0 pc/ms; moderate cataract 9.5 +/- 6.1 pc/ms; p < 0.001). In clear lenses and mild cataract, age correlated significantly with flare (two-sided, p < 0.001, clear lenses R = 0.3; mild cataract R = 0.4). In clear lenses, flare values increased with age by 0.09 per year, in mild cataract by 0.17 (regression coefficients). No significant correlation was found between age and flare value in moderate cataract and pseudophakic eyes. Conclusion The level of objective tyndallometry seems to be dependent on lens status, degree of lens opacity and age. These factors should therefore be taken into account when interpreting laser flare values in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schoeneberger, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Menghesha, Leonie UNSPECIFIED orcid.org/0000-0003-0936-2414 UNSPECIFIED Gerlach, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gietzelt, Caroline UNSPECIFIED orcid.org/0000-0002-9145-7385 UNSPECIFIED Eberhardt, Somaie UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED orcid.org/0000-0003-2648-1626 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-660271
DOI:	10.1177/11206721221137169
Journal or Publication Title:	Eur. J. Ophthalmol.
Volume:	33
Number:	2
Page Range:	S. 943 - 949
Date:	2023
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1724-6016
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL METER MEASUREMENTS; AQUEOUS FLARE; PROLIFERATIVE VITREORETINOPATHY; PROTEIN-CONCENTRATION; ANTERIOR SEGMENT; REPRODUCIBILITY; VALIDITY; AGE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66027