Universität zu Köln

Roth, Katrin S., Voltin, Conrad-Amadeus ORCID: 0000-0002-5437-3959, van Heek, Lutz, Wegen, Simone, Schomaecker, Klaus, Fischer, Thomas, Marnitz, Simone, Drzezga, Alexander and Kobe, Carsten (2022). Dual-Tracer PET/CT Protocol with [F-18]-FDG and [Ga-68]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept. J. Nucl. Med., 63 (11). S. 1683 - 1687. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Imaging studieswithPET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [F-18]-FDG in cancer imaging. Methods: All patients received [F-18]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [Ga-68]Ga-FAPI-46 after the [F-18]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT. Results: Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dualtracer PET/CT. Conclusion: Dual-tracer [F-18]-FDG/[Ga-68]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dualtracer approach may have superior sensitivity to [F-18]-FDG PET/CT alone without compromising individual assessment of either scan.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roth, Katrin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Voltin, Conrad-Amadeus UNSPECIFIED orcid.org/0000-0002-5437-3959 UNSPECIFIED van Heek, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegen, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Schomaecker, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Marnitz, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-660685
DOI:	10.2967/jnumed.122.263835
Journal or Publication Title:	J. Nucl. Med.
Volume:	63
Number:	11
Page Range:	S. 1683 - 1687
Date:	2022
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FIBROBLAST ACTIVATION PROTEIN; TARGET; FAP Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66068