Universität zu Köln

Yan, Shuaifeng, Kotschenreuther, Konstantin ORCID: 0000-0001-9455-2444, Deng, Shuya and Kofler, David M. (2022). Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential. Cell. Mol. Life Sci., 79 (10). BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are thought to play a vital role in disease onset. In the pathogenesis of autoimmune diseases, disturbed immunosuppressive properties of regulatory T cells contribute to the dysregulation of immune homeostasis. In RA patients, the functions of Treg cells and their frequency are reduced. Therefore, focusing on the re-establishment of self-tolerance by increasing Treg cell frequencies and preventing a loss of function is a promising strategy for the treatment of RA. This approach could be especially beneficial for those patients who do not respond well to current therapies. In this review, we summarize and discuss the current knowledge about the function, differentiation and regulation of Treg cells in RA patients and in animal models of autoimmune arthritis. In addition, we highlight the therapeutic potential as well as the challenges of Treg cell targeting treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yan, Shuaifeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Kotschenreuther, Konstantin UNSPECIFIED orcid.org/0000-0001-9455-2444 UNSPECIFIED Deng, Shuya UNSPECIFIED UNSPECIFIED UNSPECIFIED Kofler, David M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662016
DOI:	10.1007/s00018-022-04563-0
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	79
Number:	10
Date:	2022
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLLAGEN-INDUCED ARTHRITIS; LOW-DOSE INTERLEUKIN-2; UMBILICAL-CORD BLOOD; DENDRITIC CELLS; CUTTING EDGE; TREG CELLS; IN-VITRO; MEDIATED SUPPRESSION; ADOPTIVE TRANSFER; FOXP3 EXPRESSION Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66201