Universität zu Köln

Reimer, R. P., Zaytoun, H., Klein, K., Sonnabend, K., Lennartz, S., Zopfs, D., Heidenreich, A., Maintz, D. and Hokamp, N. Grosse (2023). Detection and size measurements of kidney stones on virtual non-contrast reconstructions derived from dual-layer computed tomography in an ex vivo phantom setup. Eur. Radiol., 33 (4). S. 2995 - 3004. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives To systematically investigate the usability of virtual non-contrast reconstructions (VNC) derived from dual-layer CT (DLCT) for detection and size measurements of kidney stones with regards to different degrees of surrounding iodine-induced attenuation and radiation dose. Methods Ninety-two kidney stones of varying size (3-14 mm) and composition were placed in a phantom filled with different contrast media/water mixtures exhibiting specific iodine-induced attenuation (0-1500 HU). DLCT-scans were acquired using CTDIvol of 2 mGy and 10 mGy. Conventional images (CI) and VNC0H-1500HU were reconstructed. Reference stone size was determined using a digital caliper (Man-M). Visibility and stone size were assessed. Statistical analysis was performed using the McNemar test, Wilcoxon test, and the coefficient of determination. Results All stones were visible on CI0HU and VNC200HU. Starting at VNC400 HU, the detection rate decreased with increasing HU and was significantly lower as compared to CI0HU on VNC >= 600HU (100.0 vs. 94.0%, p < 0.05). The overall detection rate was higher using 10 mGy as compared to 2 mGy protocol (87.9 vs. 81.8%; p < 0.001). Stone size was significantly overestimated on all VNC compared to Man-M (7.0 +/- 3.5 vs. 6.6 +/- 2.8 mm, p < 0.001). Again, the 10 mGy protocol tended to show a better correlation with Man-M as compared to 2 mGy protocol (R-2 = 0.39-0.68 vs. R-2 = 0.31-0.57). Conclusions Detection and size measurements of kidney stones surrounded by contrast media on VNC are feasible. The detection rate of kidney stones decreases with increasing iodine-induced attenuation and with decreasing radiation dose as well as stone size, while remaining comparable to CI0HU on VNC (<= 400 HU).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reimer, R. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaytoun, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sonnabend, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennartz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zopfs, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, N. Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662222
DOI:	10.1007/s00330-022-09261-w
Journal or Publication Title:	Eur. Radiol.
Volume:	33
Number:	4
Page Range:	S. 2995 - 3004
Date:	2023
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENERGY CT UROGRAPHY; STATISTICAL ITERATIVE RECONSTRUCTION; IODINE QUANTIFICATION; UROLITHIASIS; ATTENUATION; DIAGNOSIS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66222