Universität zu Köln

Walpurgis, Katja, Piper, Thomas and Thevis, Mario (2022). Androgens, sports, and detection strategies for anabolic drug use. Best Pract. Res. Clin. Endoc. Metab., 36 (4). OXFORD: ELSEVIER SCI LTD. ISSN 1532-1908

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Abstract

For decades, anabolic androgenic agents have represented the substance class most frequently observed in doping control sam-ples. They comprise synthetic and pseudoendogenous anabolic androgenic steroids and other, mostly non-steroidal compounds with (presumed) positive effects on muscle mass and function. While exogenous substances can easily be detected by gas/liquid chromatography and mass spectrometry, significantly more com-plex methodologies including the longitudinal monitoring of in-dividual urinary steroid concentrations/ratios and isotope ratio mass spectrometry are required to provide evidence for the exogenous administration of endogenous compounds. This narrative review summarizes the efforts made within the last 5 years to further improve the detection of anabolic agents in doping control samples. Different approaches such as the identi-fication of novel metabolites and biomarkers, the acquisition of complementary mass spectrometric data, and the development of new analytical strategies were employed to increase method sensitivity and retrospectivity while simultaneously reducing method complexity to facilitate a higher and faster sample throughput.(c) 2022 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walpurgis, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Piper, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662530
DOI:	10.1016/j.beem.2021.101609
Journal or Publication Title:	Best Pract. Res. Clin. Endoc. Metab.
Volume:	36
Number:	4
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1532-1908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MASS-SPECTROMETRIC CHARACTERIZATION; EXPANDING ANALYTICAL POSSIBILITIES; LONG-TERM METABOLITES; GAS-CHROMATOGRAPHY; ISOTOPE RATIO; STEROID PROFILE; HUMAN URINE; ELECTROSPRAY-IONIZATION; ENDOGENOUS STEROIDS; SULFATE METABOLITES Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66253