Universität zu Köln

Prokosch, Verena, Liu, Hanhan, Leibinger, Marco and Fischer, Dietmar (2022). Regeneration of the optic nerve-Will it one day be reality? Ophthalmologie, 119 (9). S. 919 - 929. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-7218

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Abstract

Background Adult mammalian and human neurons of the central nervous system (CNS) lack the ability to spontaneously regenerate damaged axons. This dilemma of many CNS diseases is still an unsolved problem. Objective The purpose of this article is to examine the question which options have been investigated in more detail in recent years and offer approaches. Methods A web-based search of all articles published between 1958 to the present regarding regeneration of retinal ganglion cells was carried out. Results Over the last three decades it has been shown that axonal regeneration is possible under certain conditions when intrinsic and extrinsic factors are manipulated in retinal ganglion cells and in the optic nerve. Although there is still a long way to go, experimental regenerative approaches are already visible; however, it will take several years or decades before these can be approximately implemented in practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prokosch, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Leibinger, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Dietmar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-663225
DOI:	10.1007/s00347-022-01628-0
Journal or Publication Title:	Ophthalmologie
Volume:	119
Number:	9
Page Range:	S. 919 - 929
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-7218
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETINAL GANGLION-CELLS; PROMOTES AXONAL REGENERATION; GENE-EXPRESSION; SPINAL-CORD; IN-VIVO; GROWTH; PROTEINS; SURVIVAL; EXPLANTS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66322